The presence of carcinogen‐DNA adducts in human tissues is evidence of exposure to
carcinogens and may be an indicator of cancer risk. DNA was isolated from non‐tumorous …

Purified DNA from human lung, liver, bladder, pancreas, breast and cervix has been
analysed for DNA adducts using the nuclease P1 modification of the 32P post‐labelling …

The formation of carcinogen-DNA adducts within the respiratory epithelium is thought to be a
critical factor in the induction of lung cancer from tobacco smoke. A reliable surrogate …

Covalent DNA addition products (adducts) formed by the reaction of chemical carcinogens
or their metabolites with DNA are critically involved in the initiation of chemical …

Tobacco smoking causes millions of cancer deaths annually. Tobacco smoke is a complex
mixture of thousands of chemicals including many known animal carcinogens. Because …

The 32P-post-labelling assay for DNA adduct quantification gives the opportunity to examine
endogenous exposure to DNA reactive compounds. Most human biomonitoring studies …

BACKGROUND: DNA adducts formed as a consequence of exposure to tobacco smoke may
be involved in carcinogenesis, and their presence may indicate a high risk of lung cancer …

To investigate the feasibility of measuring DNA‐carcinogen adducts in the lungs of non‐
surgical patients, endobronchial biopsies were obtained from 78 patients undergoing …

Smoking is a major risk factor for lung cancer. This comparative study of smoking-related
carcinogen–DNA adducts in pulmonary tissues and peripheral blood lymphocytes aims to …

Nasal epithelium is an easily accessible tissue that is potentially useful for human
biomonitoring studies aimed at evaluating exposure to airborne carcinogens. We have …