Transcriptional co-activator LEDGF/p75 is the major cellular interactor of HIV-1 integrase
(IN), critical to efficient viral replication. In this work, a series of INs from the Betaretrovirus …

LEDGF/p75 directly interacts with lentiviral integrase proteins and can modulate their
enzymatic activities and chromosomal association. A novel genetic knockout model was …

Retroviral replication proceeds through a stable proviral DNA intermediate, and numerous
host cell factors have been implicated in its formation. In particular, recent results have …

We have previously shown that the p75 isoform of the transcriptional co-activator lens
epithelium-derived growth factor (LEDGF) interacts tightly with human immunodeficiency …

After identifying the interaction between the transcriptional coactivator lens epithelium-
derived growth factor (LEDGF/p75) and the human immunodeficiency virus type 1 (HIV-1) …

LEDGF/p75 binding-defective IN mutant viruses were previously characterized as replication-
defective, yet RNAi did not reveal an essential role for the host factor in HIV-1 replication …

HIV integrates a DNA copy of its genome into a host cell chromosome in each replication
cycle. The essential DNA cleaving and joining chemistry of integration is known, but there is …

Integrase (IN) is an essential retroviral enzyme, and human transcriptional coactivator p75,
which is also referred to as lens epithelium-derived growth factor (LEDGF), is the dominant …

Human immunodeficiency virus type 1 (HIV-1), feline immunodeficiency virus (FIV), and
Moloney murine leukemia virus (MoMLV) integrases were stably expressed to determine …

Integration is an essential step in the retroviral lifecycle, and the lentiviral integrase binding
protein lens epithelium-derived growth factor (LEDGF)/p75 plays a crucial role during …