Autotrophic growth and ethanol production enabled by diverting acetate flux in the metabolically engineered Moorella thermoacetica

K Takemura, J Kato, S Kato, T Fujii, K Wada… - Journal of bioscience …, 2021 - Elsevier
Gas fermentation is a promising biological process for the conversion of CO 2 or syngas into
valuable chemicals. Homoacetogens are microorganisms growing autotrophically using CO …

Enhancing acetone production from H2 and CO2 using supplemental electron acceptors in an engineered Moorella thermoacetica

K Takemura, J Kato, S Kato, T Fujii, K Wada… - Journal of bioscience …, 2023 - Elsevier
Acetogens grow autotrophically and use hydrogen (H 2) as the energy source to fix carbon
dioxide (CO 2). This feature can be applied to gas fermentation, contributing to a circular …

Metabolic engineering of Moorella thermoacetica for thermophilic bioconversion of gaseous substrates to a volatile chemical

J Kato, K Takemura, S Kato, T Fujii, K Wada, Y Iwasaki… - Amb Express, 2021 - Springer
Gas fermentation is one of the promising bioprocesses to convert CO2 or syngas to
important chemicals. Thermophilic gas fermentation of volatile chemicals has the potential …

Reversible Hydrogenase Activity Confers Flexibility to Balance Intracellular Redox in Moorella thermoacetica

S Kobayashi, J Kato, K Wada, K Takemura… - Frontiers in …, 2022 - frontiersin.org
Hydrogen (H2) converted to reducing equivalents is used by acetogens to fix and
metabolize carbon dioxide (CO2) to acetate. The utilization of H2 enables not only …

Glycerol acts as alternative electron sink during syngas fermentation by thermophilic anaerobe Moorella thermoacetica

Z Kimura, A Kita, Y Iwasaki, Y Nakashimada… - Journal of bioscience …, 2016 - Elsevier
Moorella thermoacetica is an anaerobic thermophilic acetogen that is capable of fermenting
sugars, H 2/CO 2 and syngas (H 2/CO). For this reason, this bacterium is potentially useful …

Anaerobic CO2 fixation by the acetogenic bacterium Moorella thermoacetica

P Hu, H Rismani‐Yazdi, G Stephanopoulos - AIChE Journal, 2013 - Wiley Online Library
Anaerobic bacteria such as Moorella thermoacetica have the capacity of fixing carbon
dioxide with carbon monoxide and hydrogen for the production of ethanol, acetic acid, and …

Progress on bio-fixation and utilization of CO2 in acetogens driven by chemical energy

WEN Zhiqiong, LI Yuzhen - Synthetic Biology Journal, 2023 - synbioj.cip.com.cn
To promote the development of carbon utilization and biomanufacturing industry, one-
carbon substrates are expected to be the next generation feedstocks and attracted much …

Adaptation of the autotrophic acetogen Sporomusa ovata to methanol accelerates the conversion of CO2 to organic products

PL Tremblay, D Höglund, A Koza, I Bonde, T Zhang - Scientific reports, 2015 - nature.com
Acetogens are efficient microbial catalysts for bioprocesses converting C1 compounds into
organic products. Here, an adaptive laboratory evolution approach was implemented to …

Acetogenic fermentation from oxygen containing waste gas

T Mohr, A Infantes, L Biebinger, P De Maayer… - … in Bioengineering and …, 2019 - frontiersin.org
The microbial production of bulk chemicals from waste gas is becoming a pertinent
alternative to industrial strategies that rely on fossil fuels as substrate. Acetogens can use …

Genetic engineering of a thermophilic acetogen, Moorella thermoacetica Y72, to enable acetoin production

J Kato, T Fujii, S Kato, K Wada, M Watanabe… - … in Bioengineering and …, 2024 - frontiersin.org
Acetogens are among the key microorganisms involved in the bioproduction of commodity
chemicals from diverse carbon resources, such as biomass and waste gas. Thermophilic …