SGLT2 Inhibitors Are Lifesavers in Heart Failure

RR Baliga, DL Bhatt, E Bossone - Heart Failure Clinics, 2022 - heartfailure.theclinics.com
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Practical Guidance for the Use of SGLT2 Inhibitors in Heart Failure

I Cavallari, SP Crispino, A Segreti, GP Ussia… - American Journal of …, 2023 - Springer
Despite continuous advances in both diagnosis and management, heart failure (HF) still
represents a major worldwide health issue. Recently, sodium-glucose co-transporter 2 …

SGLT2 inhibitors for heart failure with reduced ejection fraction: a real EMPEROR?

E Raschi, GP Fadini, I Diemberger… - Expert Opinion on …, 2021 - Taylor & Francis
Introduction: In individuals with type 2 diabetes mellitus, sodium–glucose cotransporter 2
(SGLT2) inhibitors reduce the risk of hospitalization for heart failure and serious adverse …

Six lessons learned from the use of SGLT2 inhibitors in patients with heart failure

M Packer - Nature Reviews Cardiology, 2022 - nature.com
The totality of evidence from large-scale, randomized, controlled clinical trials and
mechanistic studies in the laboratory has provided six crucial lessons about the emerging …

SGLT2 inhibition and heart failure—current concepts

JS Custodio, AR Duraes, M Abreu… - Heart Failure …, 2018 - Springer
Type 2 diabetes mellitus (T2DM) is a major risk factor for several cardiovascular (CV)
conditions, including heart failure (HF). However, until recently, no therapy to treat patients …

SGLT2 inhibitors and their mode of action in heart failure—has the mystery been unravelled?

S Pabel, N Hamdani, M Luedde, S Sossalla - Current heart failure reports, 2021 - Springer
Purpose of review SGLT2 inhibitors (SGLT2i) are new drugs for patients with heart failure
(HF) irrespective of diabetes. However, the mechanisms of SGLT2i in HF remain elusive …

[HTML][HTML] Effects and safety of SGLT2 inhibitors compared to placebo in patients with heart failure: a systematic review and meta-analysis

D Chambergo-Michilot, A Tauma-Arrué… - IJC Heart & …, 2021 - Elsevier
Background Heart failure (HF) prognosis without therapy is poor, however introduction of a
range of drugs has improved it. We aimed to perform a systematic review on the effects and …

SGLT-2 inhibitors in patients with and without a history of heart failure: a meta-analysis

V Razuk, M Chiarito, D Cao, J Nicolas… - European Heart …, 2021 - academic.oup.com
Background Sodium-glucose co-transporter 2 (SGLT-2) inhibitors emerged as a new
groundbreaking therapy for patients with heart failure. Recent evidence showed significant …

SGLT‐2 inhibitors in heart failure: current management, unmet needs, and therapeutic prospects

CSP Lam, C Chandramouli, V Ahooja… - Journal of the American …, 2019 - Am Heart Assoc
Heart failure (HF) is a growing public health issue. As many as 1 in 5 people are expected to
develop HF during their lifetime, 1 with an estimated 63 million people affected worldwide. 2 …

Efficacy and safety of SGLT2 inhibitors in heart failure: systematic review and meta‐analysis

J Butler, MS Usman, MS Khan, SJ Greene… - ESC heart …, 2020 - Wiley Online Library
Aims We sought to conduct a meta‐analysis regarding the safety and efficacy of sodium‐
glucose co‐transporter 2 (SGLT2) inhibitors in patients with heart failure (HF). Methods and …