Five established cell lines derived from human anaplastic astrocytomas or glioblastoma
multiforme were tested for invasiveness into precultured chick heart fragments in vitro. Four …

✓ Embryonic chick heart fragments were confronted in vitro with cells from 26 freshly
resected human brain tumors. The tumor-derived cells were scored according to their …

Invasive properties of 15 continuous neurogenic rat cell lines were investigated in vitro and
were compared to their tumorigenicity in inbred BD IX rats. The cell lines were obtained by …

Malignant human glioma is characterized by an uncontrolled cell proliferation and infiltrative
growth into the brain. The mechanisms by which invasion occurs are poorly understood …

Primary malignant neoplasms of the nervous system differ from other types of malignancy in
several ways. Clinical progression is due to local invasive growth, while metastases outside …

Invasion of spheroids from 20 human primary glioblastomas into precultured fetal rat brain
tissue in culture has been studied and quantified. Between 30 and 98 percent of the normal …

The invasiveness of human intracranial tumours was studied in an organ culture system.
Biopsies from six glioblastomas, four astrocytomas, two mixed gliomas, one ependymoma …

Fifteen permanent cell lines derived from human gliomas were subcutaneously transplanted
into athymic nude mice (nu/nu genotype, NIH Swiss and BALB/c backgrounds). Four were …

The phagocytic capacity of 4 continuous rat glioma cell lines (BT2C, BT4Cn, BT5c, and 9L)
and normal BD IX fetal rat glial cells in culture has been studied. This was done by flow …

✓ Brain invasion prevents complete surgical extirpation of malignant gliomas; however,
invasive cells from distant, histologically normal brain previously have not been isolated …