Maternal obesity: new placental paradigms unfolded

C Brombach, W Tong, DA Giussani - Trends in molecular medicine, 2022 - cell.com
The prevalence of maternal obesity is increasing at an alarming rate, and is providing a
major challenge for obstetric practice. Adverse effects on maternal and fetal health are …

Placental function in maternal obesity

AC Kelly, TL Powell, T Jansson - Clinical Science, 2020 - portlandpress.com
Maternal obesity is associated with pregnancy complications and increases the risk for the
infant to develop obesity, diabetes and cardiovascular disease later in life. However, the …

Human placental adaptive changes in response to maternal obesity: sex specificities

ED Santos, MH Hernández, V Sérazin… - International Journal of …, 2023 - mdpi.com
Maternal obesity is increasingly prevalent and is associated with elevated morbidity and
mortality rates in both mothers and children. At the interface between the mother and the …

Maternal pre-pregnancy obesity is associated with altered placental transcriptome

S Altmäe, MT Segura, FJ Esteban, S Bartel, P Brandi… - PloS one, 2017 - journals.plos.org
Maternal obesity has a major impact on pregnancy outcomes. There is growing evidence
that maternal obesity has a negative influence on placental development and function …

Programming of fetal insulin resistance in pregnancies with maternal obesity by ER stress and inflammation

F Westermeier, PJ Sáez… - BioMed Research …, 2014 - Wiley Online Library
The global epidemics of obesity during pregnancy and excessive gestational weight gain
(GWG) are major public health problems worldwide. Obesity and excessive GWG are related …

Maternal obesity and the uterine immune cell landscape: the shaping role of inflammation

LE St-Germain, B Castellana, J Baltayeva… - International journal of …, 2020 - mdpi.com
Inflammation is often equated to the physiological response to injury or infection.
Inflammatory responses defined by cytokine storms control cellular mechanisms that can …

Feto-placental adaptations to maternal obesity in the baboon

D Farley, ME Tejero, AG Comuzzie, PB Higgins, L Cox… - Placenta, 2009 - Elsevier
Maternal obesity is present in 20–34% of pregnant women and has been associated with
both intrauterine growth restriction and large-for-gestational age fetuses. While fetal and …

Placental dysfunction in obese women and antenatal surveillance

A Doshani, JC Konje - Best Practice & Research Clinical Obstetrics & …, 2023 - Elsevier
Obesity is a significant health concern worldwide and is associated with numerous health
complications, including placental dysfunction during pregnancy. Placental dysfunction can …

Diabesity-associated oxidative and inflammatory stress signalling in the early human placenta

D Hoch, M Gauster, S Hauguel-de Mouzon… - Molecular aspects of …, 2019 - Elsevier
Early pregnancy is characterized by a series of complex and tightly regulated events to
ultimately establish implantation and early placental development. One of the key events is …

Early growth response protein-1 mediates lipotoxicity-associated placental inflammation: role in maternal obesity

J Saben, Y Zhong, H Gomez-Acevedo… - American Journal …, 2013 - journals.physiology.org
Obesity is associated with low-grade chronic inflammation, which contributes to cellular
dysfunction promoting metabolic disease. Obesity during pregnancy leads to a …