Background Adequate termination of an immune response is as important as the induction
of an appropriate response. CD46, a regulator of complement activity, promotes T cell …

Complement is undeniably quintessential for innate immunity by detecting and eliminating
infectious microorganisms. Recent work, however, highlights an equally profound impact of …

Following T cell receptor triggering, T cell activation is initiated and amplified by the
assembly at the TCR/CD3 macrocomplex of a multitude of stimulatory enzymes that activate …

CD46 is a cell surface protein that regulates complement activity and is utilized as a receptor
by numerous viral and bacterial pathogens that infect humans. CD46 is not just an entry site …

CD46 is a widely expressed transmembrane protein that was initially identified as binding
and inactivating C3b and C4b complement products. We used mice that were transgenic for …

CD46 is a type I transmembrane protein with complement and T cell regulatory functions in
human cells. CD46 has signaling and receptor properties in immune and nonimmune cells …

CD46 is a complement regulatory molecule expressed on every cell type, except for
erythrocytes. While initially described as a regulator of complement activity, it later became a …

The role of CD26 in human T cell biology is puzzling. Despite being extensively
characterized, it has been called 'a moonlighting protein'since it has multifunctional effects …

Although it is expressed by all leukocytes, including T-, B-lymphocytes and dendritic cells,
the immunoglobulin-like receptor CD31 is generally regarded by immunologists as a marker …

In this study we demonstrate a new form of immunoregulation: engagement on CD4+ T cells
of the complement regulator CD46 promoted the effector potential of T helper type 1 cells …