Spatial pharmacology using mass spectrometry imaging

P Rajbhandari, TV Neelakantan, N Hosny… - Trends in …, 2024 - cell.com
The emerging and powerful field of spatial pharmacology can map the spatial distribution of
drugs and their metabolites, as well as their effects on endogenous biomolecules including …

Spatial analysis of drug absorption, distribution, metabolism, and toxicology using mass spectrometry imaging

ML Spruill, M Maletic-Savatic, H Martin, F Li… - Biochemical …, 2022 - Elsevier
Mass spectrometry imaging (MSI) is emerging as a powerful analytical tool for detection,
quantification, and simultaneous spatial molecular imaging of endogenous and exogenous …

[HTML][HTML] Advances in spatial mass spectrometry enable in-depth neuropharmacodynamics

S Baijnath, I Kaya, A Nilsson, R Shariatgorji… - Trends in …, 2022 - cell.com
Mass spectrometry imaging (MSI) is a powerful technique that combines the ability of
microscopy to provide spatial information about multiple molecular species with the …

[HTML][HTML] Mass spectrometry imaging advances and application in pharmaceutical research

X Song, C Li, Y Meng - Acta Materia Medica, 2022 - ucl.scienceopen.com
Mass spectrometry imaging (MSI) has been shown to be a valuable tool through nearly
every stage of the preclinical drug research and development (R&D) pipeline, and even to …

Imaging and spatially resolved quantification of drug distribution in tissues by mass spectrometry

B Prideaux, A Lenaerts, V Dartois - Current Opinion in Chemical Biology, 2018 - Elsevier
Highlights•An overview of recent advances in MSI for drug localization is presented.•MSI
provides label-free imaging of drugs and metabolites at high lateral resolution.•Spatial …

The space dimension at the micro level: mass spectrometry imaging of drugs in tissues

E Davoli, M Zucchetti, C Matteo… - Mass spectrometry …, 2021 - Wiley Online Library
Mass spectrometry imaging (MSI) has seen remarkable development in recent years. The
possibility of getting quantitative or semiquantitative data, while maintaining the spatial …

[HTML][HTML] Qualitative and quantitative mass spectrometry imaging of drugs and metabolites in tissue at therapeutic levels

N Sun, A Walch - Histochemistry and Cell Biology, 2013 - Springer
Mass spectrometry imaging (MSI) is a rapidly evolving technology that yields qualitative and
quantitative distribution maps of small pharmaceutical-active molecules and their …

High spatial resolution mass spectrometry imaging for spatial metabolomics: advances, challenges, and future perspectives

S Ma, Y Leng, X Li, Y Meng, Z Yin, W Hang - TrAC Trends in Analytical …, 2023 - Elsevier
Spatial metabolomics is an emerging field of omics research that has enabled localizing
small molecules in tissues and cells. Mass spectrometry imaging (MSI) technologies allow …

Mass spectrometry imaging and its application in pharmaceutical research and development: A concise review

JG Swales, G Hamm, MR Clench… - International Journal of …, 2019 - Elsevier
Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …

Mass spectrometry imaging of therapeutics from animal models to three-dimensional cell cultures

X Liu, AB Hummon - Analytical chemistry, 2015 - ACS Publications
Mass spectrometry imaging (MSI) is a powerful label-free technique for the investigation of
the spatial distribution of molecules at complex surfaces and has been widely used in the …