Neuropeptide Y is a potent vasoconstrictor and a cardiodepressant in rat

Z Zukowska-Grojec, ES Marks… - American Journal of …, 1987 - journals.physiology.org
Neuropeptide Y (NPY) is contained in and coreleased with norepinephrine (NE) from
sympathetic nerves innervating vascular and cardiac tissues. The effects of NPY infusion on …

Effects of a nonpressor dose of neuropeptide Y on cardiac output, regional blood flow distribution and plasma renin, vasopressin and catecholamine levels.

JF Aubert, M Burnier, B Waeber, J Nussberger… - … of Pharmacology and …, 1988 - ASPET
Neuropeptide Y (NPY) is a peptide with vasoconstrictor properties known to be present in
the central nervous system as well as in sympathetic nerve endings and the adrenal …

Neuropeptide Y and peptide YY mediate non-adrenergic vasoconstriction and modulate sympathetic responses in rats

Z Zukowska-Grojec, M Haass, MA Bayorh - Regulatory peptides, 1986 - Elsevier
The modulation of cardiovascular sympathetic responses by neuropeptide Y (NPY) and
peptide YY (PYY) was assessed in vivo, in pithed rats. Both peptides (0.02–2 nmol/kg) …

Lack of inotropic effects of neuropeptide Y in human myocardium

MC Michel, SC Wirth, HR Zerkowski… - Journal of …, 1989 - journals.lww.com
The sympathetic co-transmitter neuropeptide Y (NPY) inhibits cardiac contractility in vivo in
the rat heart. We tested whether NPY alters the force of contraction or the activity of …

Cardiovascular effects and cardiopulmonary plasma gradients following intravenous infusion of neuropeptide Y in humans: negative dromotropic effect on …

B Ullman, J Pernow, JM Lundberg, H ÅSTRÖM… - Clinical …, 2002 - portlandpress.com
Neuropeptide Y (NPY) is co-released with noradrenaline from sympathetic nerves, has a
strong vasoconstrictive action, and causes an attenuation of parasympathetic action in …

Neuropeptide Y1-and Y2-receptor-mediated cardiovascular effects in the anesthetized guinea pig, rat, and rabbit

C Abrahamsson - Journal of cardiovascular pharmacology, 2000 - journals.lww.com
Neuropeptide Y (NPY) causes vasoconstriction through Y1-receptors and inhibits vagal
bradycardia through presynaptic Y2-receptors. These effects of NPY were investigated in …

The vasoconstrictor effect of neuropeptide Y and related peptides in the guinea pig isolated heart

F Rioux, H Bachelard, JC Martel, S St-Pierre - Peptides, 1986 - Elsevier
Neuropeptide Y (NPY) infusions into isolated, perfused, spontaneously beating hearts of
guinea pigs elicited concentration-dependent increases of myocardial perfusion pressure …

Neuropeptide Y (NPY): enhancement of blood pressure increase upon α-adrenoceptor activation and direct pressor effects in pithed rats

C Dahlöf, P Dahlöf, JM Lundberg - European journal of pharmacology, 1985 - Elsevier
The effects of neuropeptide Y (NPY) on blood pressure and heart rate were studied in pithed
rats. Systemic infusion of NPY in a dose (230 pmol× kg− 1× min− 1) which per se did not …

Distinction of NPY receptors in vitro and in vivo. II. Differential effects of NPY and NPY-(18-36)

NA Scott, MC Michel, JH Boublik… - American Journal …, 1990 - journals.physiology.org
We have studied the hemodynamic effects of neuropeptide Y (NPY) and its COOH-terminal
fragment NPY-(18–36) in conscious rats. Intra-arterial injection of NPY rapidly elevated …

Pressor effect of centrally administered neuropeptide Y in rats: role of sympathetic nervous system and vasopressin

M Vallejo, SL Lightman - Life sciences, 1986 - Elsevier
The haemodynamic effects of intracerebroventricular (icv) administration of neuropeptide Y
(NPY) in urethane-anaesthetized rats were studied. In Sprague-Dawley rats, NPY increased …