Targeted therapies against the Epidermal Growth Factor Receptor (EGFR) are useful to treat
many human cancers such as non-small cell lung cancer, colorectal cancer and head and …

Purpose: The epidermal growth factor receptor (EGFR) is recognized as a key mediator of
proliferation and progression in many human tumors. A series of EGFR-specific inhibitors …

Mechanisms of Intrinsic and Acquired Resistance to EGFR Inhibitors Page 1 276 Current Cancer
Therapy Reviews, 2007, 3, 276-283 1573-3947/07 $50.00+.00 © 2007 Bentham Science …

Abstract 5333 Although molecular inhibitors of EGFR signaling carry high promise in cancer
therapeutics, clinical trial results to date indicate that only a small subset of patients (10 …

The epidermal growth factor receptor (EGFR) is a validated molecular target in squamous
cell carcinoma of the head and neck (HNSCC). However, despite high expression levels of …

Since its discovery several decades ago, the Epidermal Growth Factor Receptor (EGFR) has
become one of the most extensively studies receptor tyrosine kinases. However, despite …

The epidermal growth factor receptor (EGFR) autocrine pathway plays a crucial role in
human cancer, contributing to a number of highly relevant processes in tumor development …

In spite of the overexpression and efficient inhibition of epidermal growth factor receptor
(EGFR), resistance to EGFR inhibitors, monoclonal antibodies and tyrosine kinase inhibitors …

The epidermal growth factor receptor (EGFR) is widely expressed in head and neck
squamous cell carcinomas (HNSCC) and activates many growth and survival pathways …

In recent years, the epidermal growth factor receptor (EGFR) has been recognized as a
central player and regulator of cancer cell proliferation, apoptosis and angiogenesis and …