Pex19p, a soluble cytoplasmic transport protein, is required for the traffic of the peroxisomal
membrane proteins Pex3p and Pex15p from the endoplasmic reticulum (ER) to the …

Two distinct pathways have recently been proposed for the import of peroxisomal membrane
proteins (PMPs): a Pex19p-and Pex3p-dependent class I pathway and a Pex19p-and Pex3p …

Tail-anchored proteins contain a single transmembrane domain (TMD) followed by a short C-
terminal domain extending into the organellar lumen. Tail-anchored proteins are thought to …

Author Summary Fig. 1. The manufacture and shipment of proteins within a cell. Together,
the ER (yellow) and the membrane surrounding the nucleus (yellow) constitute an assembly …

Pex7p is the soluble receptor responsible for importing into peroxisomes newly synthesized
proteins bearing a type 2 peroxisomal targeting sequence. We observe that appending GFP …

Several yeast and mammalian peroxisomal membrane proteins (PMPs) are delivered to
peroxisomes via the endoplasmic reticulum (ER). Fluorescence microscopy showed a …

Pex3 has been proposed to be important for the exit of peroxisomal membrane proteins
(PMPs) from the ER, based on the observation that PMPs accumulate at the ER in …

Biogenesis of the mammalian peroxisomal membrane requires the action of Pex3p and
Pex16p, two proteins present in the organelle membrane, and Pex19p, a protein that …

PEX19 is a chaperone and import receptor for newly synthesized, class I peroxisomal
membrane proteins (PMPs). PEX19 binds these PMPs in the cytoplasm and delivers them to …

We identified a Saccharomyces cerevisiae peroxisomal membrane protein, Pex13p, that is
essential for protein import. A point mutation in the COOH-terminal Src homology 3 (SH3) …