Interference in insulin and/or insulin-like growth factor 1 (IGF-1) signaling can extend
invertebrate life span, and interference in IGF-1 signaling can extend murine life span …

Insulin/insulin-like growth factor-I (IGF-I) pathways are recognized as critical signaling
pathways involved in the control of lifespans in lower organisms to mammals. Caloric …

In invertebrates, signaling pathways homologous to mammalian insulin and insulin-like
growth factor (IGF-1) signal transduction have a major role in the control of longevity. There …

Recent evidence suggests that alterations in insulin/insulin–like growth factor 1 (IGF1)
signaling (IIS) can increase mammalian life span. For example, in several mouse mutants …

Impaired insulin/IGF 1 signalling has been shown to extend lifespan in model organisms
ranging from yeast to mammals. Here we sought to determine the effect of targeted …

Research with invertebrates over the past 10 years has suggested that alterations in insulin
and/or insulin-like growth factor I (IGF-I) signalling result in increased lifespan and retard …

Mutations in insulin/IGF-1 signaling pathway have been shown to lead to increased
longevity in various invertebrate models. Therefore, the effect of the haplo-insufficiency of …

Recent studies have shown that insulin and insulin-like growth factor (IGF)-1 signaling are
involved in the control of ageing and longevity in model organisms. Based on these studies …

Ageing may be controlled by a genetic-hormonal system that may have originated from a
very early common ancestor. One of the pathways that has been implicated in ageing is the …

It has been demonstrated in invertebrate species that the evolutionarily conserved insulin
and insulin-like growth factor (IGF) signaling (IIS) pathway plays a major role in the control of …