IgM antibodies constitute the major component of the natural antibodies and is also the first
class of antibodies produced during a primary antibody response. The IgM-type antibodies …

Attempting to obtain a representative sample of the “natural antibody” repertoire in the
developing immune system, we have derived IgM‐secreting hybridomas from 4 normal …

B cells express antigen, Fc and complement receptors on their surfaces and can thus bind
all three components of an immune complex. In addition to the direct effects that they exert …

It is now well known that B cells characteristically express immunoglobulin receptors on their
surface. On average, each B lymphocyte bears approximately 10^ immunoglobulin …

Natural autoantibodies are primarily immunoglobulin M (IgM) antibodies that bind to a
variety of self-antigens, including self-IgG. Accounting for a large proportion of the early B …

Injection in normal mice of IgM antibodies against sheep erythrocytes or dextran, in the form
of an immune serum depleted og IgG, induces direct plaque-forming cells of the same …

The nucleotide sequences of heavy and light chains from 10 monoclonal IgM anti-IgG1 (RF)
antibodies were determined and reported here as translated amino acid sequences. Only …

The nature and function ofthe membrane-bound immunoglobulin (mig) of B lymphocytes
have presented a challenge to immunologists since Ehrlich in 1900 first proposed the …

Natural immunoglobulin M (IgM) antibodies are pentameric or hexameric macro-
immunoglobulins and have been highly conserved during evolution. IgMs are initially …

We have investigated the autoreactive repertoire expressed by serum IgG of healthy
individuals of various age groups using a large panel of self antigens. Natural IgG …