Using heparin molecules to manage COVID‐2019

J Liu, J Li, K Arnold, R Pawlinski… - Research and practice …, 2020 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic is becoming one of the
largest global public health crises in modern history. The race for an effective drug to prevent …

Comprehensive landscape of heparin therapy for COVID-19

C Shi, W Tingting, JP Li, MA Sullivan, C Wang… - Carbohydrate …, 2021 - Elsevier
The pandemic coronavirus disease 2019 (COVID-19), caused by the infection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is rapidly spreading globally …

Heparin as a therapy for COVID-19: current evidence and future possibilities

JA Hippensteel, WB LaRiviere… - … of Physiology-Lung …, 2020 - journals.physiology.org
Coronavirus disease 2019 (COVID-19), the clinical syndrome associated with infection by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has impacted nearly every …

[HTML][HTML] Inhaled and systemic heparin as a repurposed direct antiviral drug for prevention and treatment of COVID-19

C Conzelmann, JA Müller, L Perkhofer, KMJ Sparrer… - Clinical Medicine, 2020 - Elsevier
Here, we advocate a highly favourable opportunity for the treatment of COVID-19 disease by
repurposing a long-serving medical agent with an excellent history of clinical use, namely …

Beneficial non-anticoagulant mechanisms underlying heparin treatment of COVID-19 patients

B Buijsers, C Yanginlar, ML Maciej-Hulme… - …, 2020 - thelancet.com
Abstract Coronavirus disease-2019 (COVID-19) is associated with severe inflammation in
mainly the lung, and kidney. Reports suggest a beneficial effect of the use of heparin/low …

Heparin: An old drug for new clinical applications

P Wang, L Chi, Z Zhang, H Zhao, F Zhang… - Carbohydrate …, 2022 - Elsevier
Heparin, an old but first-line anticoagulant, has been used over a century. It is a
heterogeneous, linear, highly sulfated, anionic glycosaminoglycan with a broad distribution …

Heparin–an old drug with multiple potential targets in Covid‐19 therapy

U Lindahl, JP Li - Journal of Thrombosis and Haemostasis, 2020 - jthjournal.org
2. Dianne K, Jennings I, Kitchen S, Walker I. Letter in response to article “Systematic review
of viscoelastic testing (TEG/Rotem) in obstetrics and recommendations from the women's …

The potential role of heparin in patients with COVID-19: beyond the anticoagulant effect. A review

L Gozzo, P Viale, L Longo, DC Vitale… - Frontiers in …, 2020 - frontiersin.org
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is responsible of
variable clinical manifestations, ranging from no symptoms to severe pneumonia with acute …

The role of heparin in COVID-19: an update after two years of pandemics

M Mangiafico, A Caff, L Costanzo - Journal of Clinical Medicine, 2022 - mdpi.com
Coronavirus disease 2019 (COVID-19) is associated with an increased risk of venous
thromboembolism (VTE) and coagulopathy, especially in critically ill patients. Endothelial …

Unfractionated heparin inhibits live wild type SARS‐CoV‐2 cell infectivity at therapeutically relevant concentrations

JA Tree, JE Turnbull, KR Buttigieg… - British Journal of …, 2021 - Wiley Online Library
Background and Purpose Currently, there are no licensed vaccines and limited antivirals for
the treatment of COVID‐19. Heparin (delivered systemically) is currently used to treat …