Metabolic adaptation to the host environment has been recognized as an essential
mechanism of pathogenicity and the growth of Mycobacterium tuberculosis (Mtb) in the …

Central carbon metabolism (CCM)—defined as the enzymatic transformation of carbon
through glycolysis, the pentose phosphate pathway (PPP), the citric acid cycle, the …

Mycobacterium tuberculosis (Mtb), a pathogenic bacterium, is the causative agent in the vast
majority of human tuberculosis (TB) cases. Nearly one-third of the world's population has …

Background: Mycobacterium tuberculosis continues to be a major pathogen in the third
world, killing almost 2 million people a year by the most recent estimates. Even in …

Background The effectiveness of current therapeutic regimens for Mycobacterium
tuberculosis (Mtb) is diminished by the need for prolonged therapy and the rise of drug …

The emergence of multidrug resistant varieties of Mycobacterium tuberculosis has led to a
search for novel drug targets. We have performed an insilico comparative analysis of …

Drug-resistant tuberculosis (TB), which results mainly from the selection of naturally resistant
strains of Mycobacterium tuberculosis (MTB) due to mismanaged treatment, poses a severe …

We have carried out weighted gene co-expression network analysis of Mycobacterium
tuberculosis to gain insights into gene expression architecture during log phase growth. The …

Background Mycobacterium tuberculosis is one of the deadliest pathogens in humans. Co-
infection of M. tuberculosis with HIV and the emergence of multi-drug-resistant tuberculosis …

Abstract Background Up to date, Mycobacterium tuberculosis (Mtb) remains as the worst
intracellular killer pathogen. To establish infection, inside the granuloma, Mtb reprograms its …