The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy

A Iorga, CM Cunningham, S Moazeni… - Biology of sex …, 2017 - Springer
Epidemiologic studies have previously suggested that premenopausal females have
reduced incidence of cardiovascular disease (CVD) when compared to age-matched males …

Estrogens in vascular biology and disease: where do we stand today?

JF Arnal, PY Scarabin, F Trémollières… - Current Opinion in …, 2007 - journals.lww.com
Estrogens in vascular biology and disease: where do we stand... : Current Opinion in
Lipidology Estrogens in vascular biology and disease: where do we stand today? : Current …

Animal models of the cardiovascular effects of exogenous hormones

RH Karas - The American journal of cardiology, 2002 - Elsevier
As early as the 1950s, animal studies showed that exogenous estrogen could inhibit
coronary atherosclerosis. Since then, additional animal studies have helped to further …

17β-Estradiol inhibits proliferation and migration of human vascular smooth muscle cells: similar effects in cells from postmenopausal females and in males

D Dai-Do, E Espinosa, G Liu, TJ Rabelink… - Cardiovascular …, 1996 - academic.oup.com
Objectives: Cardiovascular disease is rare in premenopausal women, but increases after the
menopause when hormone replacement therapy reduces coronary events. Vascular smooth …

Sex hormone replacement therapy and modulation of vascular function in cardiovascular disease

VV Koledova, RA Khalil - Expert Review of Cardiovascular …, 2007 - Taylor & Francis
Epidemiological and experimental studies suggest vascular protective effects of estrogen.
Cardiovascular disease (CVD) is less common in premenopausal women than in men and …

Various actions of oestrogens on the vascular system

JC Stevenson - Maturitas, 1998 - Elsevier
Epidemiological studies show a reduction in cardiovascular disease with postmenopausal
oestrogen use. Oestrogens have been shown to have both metabolic effects and direct …

Understanding the controversy about hormonal replacement therapy: insights from estrogen effects on experimental and clinical atherosclerosis.

JF Arnal, V Douin-Echinard, F Tremollières… - … des Maladies du …, 2007 - europepmc.org
Whereas hormonal replacement/menopause therapy (HRT) in post-menopausal women
increases the coronary artery risk, epidemiological studies (protection in pre-menopaused …

Increased 2-methoxyestradiol production in human coronary versus aortic vascular cells

LC Zacharia, EK Jackson, DG Gillespie, RK Dubey - Hypertension, 2001 - Am Heart Assoc
Estradiol may be cardioprotective; however, the mechanisms involved remain unclear.
Recent findings that estradiol attenuates neointima formation in estrogen receptor knockout …

Mechanisms whereby oestrogens influence arterial health

JC Stevenson - European Journal of Obstetrics & Gynecology and …, 1996 - Elsevier
Coronary heart disease (CHD) is uncommon in premenopausal women compared with men
of similar age, but its incidence increases after the menopause to reach that of men. There is …

Estrogen receptors and endothelium

JF Arnal, C Fontaine, A Billon-Galés… - … and Vascular Biology, 2010 - Am Heart Assoc
Estrogens, and in particular 17β-estradiol (E2), play a pivotal role in sexual development
and reproduction and are also implicated in a large number of physiological processes …