The free radical basis of air pullution: focus on ozone

FJ Kelly, I Mudway, MT Krishna, ST Holgate - Respiratory medicine, 1995 - Elsevier
Until the middle of the present century, urban populations in the United Kingdom suffered
major health problems from air pollution, due principally to the burning of coal for domestic …

Air pollution: II--Road traffic and modern industry.

F Godlee - BMJ: British Medical Journal, 1991 - ncbi.nlm.nih.gov
Summer smog is a cocktail of volatile hydrocarbons, oxides of nitrogen, sulphur dioxide, and
carbon monoxide emitted from road vehicles, industry, and power stations. When acted on …

Differential depletion of human respiratory tract antioxidants in response to ozone challenge

IS Mudway, D Housley, R Eccles, RJ Richards… - Free radical …, 1996 - Taylor & Francis
The toxicity of ozone, the major component of photochemical smog, is related to its powerful
oxidising ability, and many of its deleterious effects are mediated through free radical …

Ozone and the lung: a sensitive issue

IS Mudway, FJ Kelly - Molecular aspects of medicine, 2000 - Elsevier
Ozone is a powerful oxidant and toxic air pollutant. As a gaseous pollutant, its primary target
tissue is the lung and breathing slightly elevated concentrations of ozone results in a range …

Biochemical basis of ozone toxicity

MG Mustafa - Free Radical Biology and Medicine, 1990 - Elsevier
Ozone (O 3) is the major oxidant of photochemical smog. Its biological effect is attributed to
its stability to cause oxidation or peroxidation of biomolecules directly and/or via free radical …

[HTML][HTML] Environmental air pollution

V Stone - American journal of respiratory and critical care …, 2000 - atsjournals.org
The effects of air pollution on health have been recognized for many hundreds of years. In
London, during December 1952, a particularly bad smog, which involved extreme elevations …

Modeling the interactions of ozone with pulmonary epithelial lining fluid antioxidants

IS Mudway, FJ Kelly - Toxicology and applied pharmacology, 1998 - Elsevier
Water soluble antioxidant—ascorbate (AA), urate (UA), and reduced glutathione (GSH)—
consumption by ozone (O3) was investigated in a range of pulmonary epithelial lining fluid …

Ozone: an overview of its toxicity in man and animals

DB Menzel - 1984 - Taylor & Francis
Ozone is one of the most toxic and ubiquitous air pollutants. This review focuses on the toxic
effects of ozone in animals and on the similarities and disimilarities between the toxic effects …

The cascade mechanism to explain ozone toxicity: the role of lipid ozonation products

WA Pryor, GL Squadrito, M Friedman - Free Radical Biology and Medicine, 1995 - Elsevier
Ozone is so reactive that it can be predicted to be entirely consumed as it passes through
the first layer of tissue it contacts at the lung/air interface. This layer includes the lung lining …

Is it true that ozone is always toxic? The end of a dogma

V Bocci - Toxicology and applied pharmacology, 2006 - Elsevier
There are a number of good experimental studies showing that exposure by inhalation to
prolonged tropospheric ozone damages the respiratory system and extrapulmonary organs …