Background The presence of water channel proteins, aquaporins (AQPs), in the brain led to
intense research in understanding the underlying roles of each of them under normal …

In cerebrovascular disease, edema formation is frequently observed within the first 7 days
and is characterized by molecular and cellular changes in the neurovascular unit. The …

Water homeostasis in the brain is of central physiologic and clinical importance. Neuronal
activity and ion water homeostasis are inextricably coupled. For example, the clearance of …

The regulation of water balance in the brain is crucial. A disruption in this equilibrium causes
an increase in brain water content that significantly contributes to the pathophysiology of …

In this review, we have tried to summarize most available data dealing with the aquaporin
(AQP) family of water channels in the CNS. Two aquaporins have been identified so far in …

Aquaporins (AQPs) mediate water flux between the four distinct water compartments in the
central nervous system (CNS). In the present chapter, we mainly focus on the expression …

Emerging evidence suggests that brain aquaporins (AQP) play important roles for the
dynamic regulation of brain water homeostasis and for the regulation of cerebrospinal fluid …

The aquaporin channel family was first considered as a family of water channels, however it
is now clear that some of these channels are also permeable to small solutes such glycerol …

ABSTRACT Introduction: Aquaporin-4 (AQP4) is a water transporting protein expressed at
the plasma membrane of astrocytes throughout the central nervous system (CNS). Analysis …

Aquaporins (AQPs) represent a diverse family of membrane proteins found in prokaryotes
and eukaryotes. The primary aquaporins expressed in the mammalian brain are AQP1 …