Adhesion-mediated signaling provides cells with information about multiple parameters of
their microenvironment, including mechanical characteristics. Often, such signaling is based …

▪ Abstract The conversion of physical signals, such as contractile forces or external
mechanical perturbations, into chemical signaling events is a fundamental cellular process …

▪ Abstract Mechanical forces play an important role in the organization, growth, maturation,
and function of living tissues. At the cellular level, many of the biological responses to …

The molecular mechanisms by which physical forces control tissue development are
beginning to be elucidated. Sites of adhesion between both cells and the extracellular …

Adhesion-dependent cells actively sense the mechanical properties of their environment
through mechanotransductory processes at focal adhesions, which are integrin-based …

Cells integrate biochemical and mechanical information to function within multicellular
tissue. Within developing and remodeling tissues, mechanical forces contain instructive …

Cell adhesion systems are defined by their ability to resist detachment force. Our
understanding of the biology of cell–cell adhesions has recently been transformed by the …

Actomyosin contractility affects cellular organization within tissues in part through the
generation of mechanical forces at sites of cell–matrix and cell–cell contact. While increased …

Integrin-mediated adhesions between cells and the extracellular matrix are fundamental for
cell function, and one of their main roles is to sense and respond to mechanical force. Here …

Physical forces regulate numerous biological processes during development, physiology,
and pathology. Forces between the external environment and intracellular actin cytoskeleton …