Next-generation sequencing technology has created many new opportunities for clinical
diagnostics, but it faces the challenge of functional annotation of identified mutations …

Every year, more than 19 million cancer cases are diagnosed, and this number continues to
increase annually. Since standard treatment options have varying success rates for different …

Most of somatic mutations in cancer occur outside of gene coding regions. These mutations
may disrupt the gene regulation by affecting protein-DNA interaction. A study of these …

The progress of cancer genome sequencing projects yields unprecedented information of
mutations for numerous patients. However, the complexity of mutation profiles of cancer …

PredictONCO 1.0 is a unique web server that analyzes effects of mutations on proteins
frequently altered in various cancer types. The server can assess the impact of mutations on …

Background: The mutations driving cancer are being increasingly exposed through tumor-
specific genomic data. However, differentiating between cancer-causing driver mutations …

Oncogenic mutations are associated with the activation of key pathways necessary for the
initiation, progression and treatment-evasion of tumors. While large genomic studies provide …

Several knowledgebases are manually curated to support clinical interpretations of
thousands of hotspot somatic mutations in cancer. However, discrepancies or even …

The vast amount of available sequencing data allows the scientific community to explore
different genetic alterations that may drive cancer or favor cancer progression. Software …

Background The initiation and subsequent evolution of cancer are largely driven by a
relatively small number of somatic mutations with critical functional impacts, so-called driver …