Management of chronic pain is a real challenge, and current treatments that focus on
blocking neurotransmission in the pain pathway have resulted in limited success. Activation …

Chronic pain, a pathological state, affects millions of people worldwide. Despite decades of
study on the neuronal processing of pain, mechanisms underlying the creation and …

Interactions between central glial cells and neurons in the pain circuitry are critical
contributors to the pathogenesis of chronic pain. In the central nervous system (CNS), two …

Glia have emerged as key contributors to pathological and chronic pain mechanisms. On
activation, both astrocytes and microglia respond to and release a number of signalling …

During neuropathic pain, glial cells (mainly astrocytes and microglia) become activated and
initiate a series of signaling cascades that modulate pain processing at both spinal and …

Clinical management of chronic pain after nerve injury (neuropathic pain) and tumor
invasion (cancer pain) is a real challenge due to our limited understanding of the cellular …

Neuropathic pain refers to a variety of chronic pain conditions with differing underlying
pathophysiologic mechanisms and origins. Recent studies indicate a communication …

Over the past few years, the control of pain exerted by glial cells has emerged as a
promising target against pathological pain. Indeed, changes in glial phenotypes have been …

Pain is classically viewed as being mediated solely by neurons, as are other sensory
phenomena. The discovery that spinal cord glia (microglia and astrocytes) amplify pain …

Development of next-generation analgesics requires a better understanding of the
molecular and cellular mechanisms underlying pathological pain. Accumulating evidence …