Objective This study investigated whether chondrocytes within the cartilage matrix have the
capacity to communicate through intercellular connections mediated by voltage-gated gap …

Objective The development of chondrocytic cell lines has enabled the investigation of the
role of cellular phenotype and mechanisms in articular cartilage biology and …

Osteoarthritis (OA) is the most common joint disease and involves progressive degeneration
of articular cartilage. The aim of this study was to investigate if chondrocytes from human …

We have previously reported that articular chondrocytes in tissue contain long cytoplasmic
arms that physically connect two distant cells. Cell-to-cell communication occurs through …

Cell-to-cell communication between bone, cartilage and the synovial membrane is not fully
understood and it is only attributed to the diffusion of substances through the extracellular …

The distribution, expression, and functionality of gap junctions was examined in bovine
chondrocytes (BCs) isolated from mature articular cartilage. BC cells displayed …

Purposes: Gap junction intercellular communication (GJIC) exhibits a key role in maintaining
the homeostasis of articular cartilage. Connexin43 (Cx43) protein is predominant in the …

Chondrocytes in cartilage and bone cells population express connexin43 (Cx43) and gap
junction intercellular communication (GJIC) is essential to synchronize cells for coordinated …

Background Recent work has shown that the gap junction protein connexin43 (Cx43) is
upregulated in cells of the joint during osteoarthritis (OA). Here we examined if the OA …

Summary Objective Connexin (Cx) 43 hemichannels play a role in mechanotransduction.
This study was undertaken in order to determine if Cx43 hemichannels were activated in rat …