[^ 3H]-CGP 39653 Mapping of Glutamatergic N-Methyl-D-Aspartate Receptors in the Brain of Aged Rats

M Cimino, P Marini, S Colombo, F Cattabeni… - Neuroscience …, 1993 - hero.epa.gov
The distribution of glutamatergic N-methyl-D-aspartate (NMDA) receptors in the rat brain
was investigated by tissue section autoradiography using the new radiolabeled, high affinity …

Influence of age on N‐methyl‐D‐aspartate antagonist binding sites in the rat brain studied by in vitro autoradiography

R Miyoshi, S Kito, N Doudou, T Nomoto - Synapse, 1991 - Wiley Online Library
The N‐methyl‐D‐aspartate (NMDA) receptor complex has been considered to consist of an
L‐glutamate recognition site, a strychine‐insensitive glycine modulatory site, and a voltage …

N-methyl-D-aspartate receptor binding in brains of rats at different ages

A Shimada, A Mukhin, DK Ingram, ED London - Neurobiology of aging, 1997 - Elsevier
Potential age differences in N-methyl-D-aspartate (NMDA) receptor binding were evaluated
in rat brain using [3H] dizocilpine and [3H] D, L-(E)-2-amino-4-propyl-5-phosphono-3 …

N-methyl-D-aspartate receptor complex in the hippocampus of elderly, normal individuals and those with Alzheimer's disease

J Ułas, LC Brunner, JW Geddes, W Choe, CW Cotman - Neuroscience, 1992 - Elsevier
The various ligand binding sites of the N-methyl-d-aspartate receptor complex in the
hippocampal formation and parahippocampal gyrus of Alzheimer's disease patients and age …

[3H] CGP 39653: a new N-methyl-D-aspartate antagonist radioligand with low nanomolar affinity in rat brain

MA Sills, G Fagg, M Pozza, C Angst… - European journal of …, 1991 - Elsevier
Abstract CGP 39653 (D, L-(E)-2-amino-4-propyl-5-phosphono-3-pentenoic acid) was initially
discovered to inhibit the binding of [3 H] L-glutamate and [3 H] 3-((±) 2-carboxypiperazin-4 …

Adaptive changes in the NMDA receptor complex in rat hippocampus after chronic treatment with CGP 39551

T Mennini, A Miari, ML Presti, M Rizzi… - European journal of …, 1994 - Elsevier
Chronic treatment of adult rats with dl-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic
carboxyethylester (CGP 39551)(30 mg/kg orally for 12 days) induced a significant increase …

Regionally different N‐methyl‐D‐aspartate receptors distinguished by ligand binding and quantitative autoradiography of [3H]‐CGP 39653 in rat brain

M Mugnaini, FTM van Amsterdam… - British journal of …, 1996 - Wiley Online Library
1 Binding of D, L‐(E)‐2‐amino‐4‐[3H]‐propyl‐5‐phosphono‐3‐pentenoic acid ([3H]‐CGP
39653), a high affinity, selective antagonist at the glutamate site of the N‐methyl‐D …

Quantitative autoradiographic localization of NMDA receptors in rat brain using [3H] CPP: comparison with [3H] TCP binding sites

MF Jarvis, DE Murphy, M Williams - European journal of pharmacology, 1987 - Elsevier
The regional distribution of N-methyl-D-aspartate (NMDA) receptors in rat brain using the
selective NMDA receptor ligand [3 H] 3-((±)-2-carboxypiperazin-4-yl) propyl-1-phosphonic …

Age-related changes in glutamate receptors: an autoradiographic analysis.

J Wardas, M Pietraszek, G Schulze… - Polish journal of …, 1997 - europepmc.org
The aim of the present study was to evaluate age-related changes in NMDA and AMPA
receptors in old female rats. To this end a quantitative autoradiography of [3H]-MK-801 and …

Age-related decreases of the N-methyl-D-aspartate receptor complex in the rat cerebral cortex and hippocampus

M Tamaru, Y Yoneda, K Ogita, J Shimizu, Y Nagata - Brain research, 1991 - Elsevier
Binding activities of central excitatory amino acid receptors were examined in Triton-treated
membrane preparations of the cerebral cortex and hippocampus from brains of rats at 2, 7 …