DNA-damaging agents such as cisplatin arrest cell cycle progression at either the G1, S, or
G2 phase, although the G1 arrest is seen only in cells expressing the wild-type p53 tumor …

A variety of agents, such as caffeine, have been shown to abrogate the DNA damage-
dependent G2 checkpoint and enhance cytotoxicity. However, these agents are too toxic for …

7-hydroxystaurosporine (UCN-01) is a more selective protein kinase C inhibitor than
staurosporine. UCN-01 exhibits antitumor activity in experimental tumor models and is …

Staurosporine is a potent but non-specific kinase inhibitor. It has served as synthetic
template for a variety of analogues, the indolocarbazoles, UCN-01 and CGP 41251, and the …

Hydroxystaurosporine (UCN-01) is a selective protein kinase C inhibitor in clinical trial for
cancer treatment. In this study, we found that nanomolar concentrations of camptothecin …

DNA-damaging agents arrest cell cycle progression at either G1 or G2. A variety of agents
such as caffeine have been shown to abrogate the DNA damage-dependent G2 checkpoint …

Purpose We evaluated the combination of UCN-01 plus cisplatin and sought to determine
how the cell cycle effects of each agent affected the combined response. Cisplatin-induced …

In response to DNA damage, cells arrest progression through the cell cycle at either G1, S,
or G2. We have reported that UCN-01 (7-hydroxystaurosporine) abrogates DNA damage …

This review summarises the evidence for the potential antineoplastic activity of the
staurosporine analogues 7-hydroxystaurospine (UCN-01) and N-benzoylstaurosporine …

Abstract Background: UCN-01 (7-hydroxy-staurosporine) is a novel antineoplastic agent
targeting cyclin-dependent kinases, which shows potent in vitro and in vivo activity against a …