Xenobiotic-induced aggravation of metabolic-associated fatty liver disease

J Massart, K Begriche, A Corlu, B Fromenty - International Journal of …, 2022 - mdpi.com
Metabolic-associated fatty liver disease (MAFLD), which is often linked to obesity,
encompasses a large spectrum of hepatic lesions, including simple fatty liver …

Metabolic dysfunction-associated steatohepatitis and progression to hepatocellular carcinoma: a literature review

H Ghazanfar, N Javed, A Qasim, GS Zacharia… - Cancers, 2024 - mdpi.com
Simple Summary The global prevalence of metabolic-associated fatty liver disease (MAFLD)
is rising due to urbanization, obesity, poor diet, sedentary lifestyles, and genetic factors. We …

High fat diet-triggered non-alcoholic fatty liver disease: A review of proposed mechanisms

CY Lian, ZZ Zhai, ZF Li, L Wang - Chemico-biological interactions, 2020 - Elsevier
Obesity is characterized by the deposition of excessive body fat, and is caused by energy
imbalance, especially when consuming fat-rich diets. High fat diet (HFD)-associated obesity …

Metabolism-disrupting chemicals affecting the liver: screening, testing, and molecular pathway identification

K Fritsche, A Ziková-Kloas, P Marx-Stoelting… - International Journal of …, 2023 - mdpi.com
The liver is the central metabolic organ of the body. The plethora of anabolic and catabolic
pathways in the liver is tightly regulated by physiological signaling but may become …

Mechanisms linking metabolic-associated fatty liver disease (MAFLD) to cardiovascular disease

OO Badmus, TD Hinds Jr, DE Stec - Current hypertension reports, 2023 - Springer
Abstract Purpose of Review Metabolic-associated fatty liver disease (MAFLD) is a condition
of fat accumulation in the liver that occurs in the majority of patients in combination with …

Role of endocrine-disrupting chemicals in the pathogenesis of non-alcoholic fatty liver disease: a comprehensive review

R Cano, JL Pérez, LA Dávila, Á Ortega… - International Journal of …, 2021 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is considered the most common liver disorder,
affecting around 25% of the population worldwide. It is a complex disease spectrum, closely …

Mitochondrial Dysfunction in Metabolic Dysfunction Fatty Liver Disease (MAFLD)

Y Zhao, Y Zhou, D Wang, Z Huang, X Xiao… - International Journal of …, 2023 - mdpi.com
Nonalcoholic fatty liver disease (NAFLD) has become an increasingly common disease in
Western countries and has become the major cause of liver cirrhosis or hepatocellular …

Detailed molecular mechanisms involved in drug-induced non-alcoholic fatty liver disease and non-alcoholic steatohepatitis: An update

LG Di Pasqua, M Cagna, C Berardo, M Vairetti… - Biomedicines, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) are
some of the biggest public health challenges due to their spread and increasing incidence …

Molecular mechanisms of hepatic lipid accumulation in non-alcoholic fatty liver disease

DH Ipsen, J Lykkesfeldt, P Tveden-Nyborg - Cellular and molecular life …, 2018 - Springer
Non-alcoholic fatty liver disease (NAFLD) is currently the world's most common liver
disease, estimated to affect up to one-fourth of the population. Hallmarked by hepatic …

Oxysterols induce mitochondrial impairment and hepatocellular toxicity in non-alcoholic fatty liver disease

F Bellanti, D Mitarotonda, R Tamborra, M Blonda… - Free Radical Biology …, 2014 - Elsevier
Non-alcoholic fatty liver disease (NAFLD) is a chronic hepatic disorder affecting up to 25% of
the general population. Several intracellular events leading to NAFLD and progression to …