Synthesis, chemical characterization, and biological evaluation of a novel auranofin derivative as an anticancer agent
A novel gold (I) complex inspired by the known medicinal inorganic compounds auranofin
and thimerosal, namely ethylthiosalicylate (triethylphosphine) gold (I)(AFETT hereafter), was …
and thimerosal, namely ethylthiosalicylate (triethylphosphine) gold (I)(AFETT hereafter), was …
Chemical modification of Auranofin yields a new family of anticancer drug candidates: the gold (I) phosphite analogues
A panel of four novel gold (I) complexes, inspired by the clinically established gold drug
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …
auranofin (1-Thio-β-D-glucopyranosatotriethylphosphine gold-2, 3, 4, 6-tetraacetate), was …
Novel gold (I) thiolate derivatives synergistic with 5-fluorouracil as potential selective anticancer agents in colon cancer
E Atrian-Blasco, S Gascon… - Inorganic …, 2017 - ACS Publications
New gold (I) thiolate complexes have been synthesized and characterized, and their
physicochemical properties and anticancer activity have been tested. The coordination of …
physicochemical properties and anticancer activity have been tested. The coordination of …
Structural and solution chemistry, antiproliferative effects, and serum albumin binding of three pseudohalide derivatives of auranofin
Three pseudohalide analogues of the established gold drug auranofin (AF hereafter), of
general formula Au (PEt 3) X, ie Au (PEt 3) CN, Au (PEt 3) SCN and Au (PEt 3) N 3 …
general formula Au (PEt 3) X, ie Au (PEt 3) CN, Au (PEt 3) SCN and Au (PEt 3) N 3 …
Structure-activity relationships in a series of auranofin analogues showing remarkable antiproliferative properties
The antiproliferative properties of a series of structurally-related gold (I) and silver (I) linear
complexes inspired to the clinically established gold-based drug auranofin were …
complexes inspired to the clinically established gold-based drug auranofin were …
Strategies for the design of analogs of auranofin endowed with anticancer potential
Introduction Auranofin (AF) is a well-established, FDA-approved, antiarthritic gold drug that
is currently being reevaluated for a variety of therapeutic indications through drug …
is currently being reevaluated for a variety of therapeutic indications through drug …
NHC gold halide complexes derived from 4, 5-diarylimidazoles: synthesis, structural analysis, and pharmacological investigations as potential antitumor agents
W Liu, K Bensdorf, M Proetto, U Abram… - Journal of medicinal …, 2011 - ACS Publications
A series of novel neutral NHC gold halide complexes derived from 4, 5-diarylimidazoles
were synthesized, characterized, and analyzed for biological effects. High growth inhibitory …
were synthesized, characterized, and analyzed for biological effects. High growth inhibitory …
Potential anticancer activity of auranofin
T Onodera, I Momose, M Kawada - Chemical and Pharmaceutical …, 2019 - jstage.jst.go.jp
Gold compounds have a long history of use in medicine. Auranofin was developed more
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …
than 30 years ago as an oral therapy for rheumatoid arthritis. Now, however, auranofin is …
Cobaltoceniumethynyl gold (I) as an unusual heterodinuclear bioorganometallic fragment to study the biological properties of alkynyl gold complexes
S Vanicek, H Kopacka, K Wurst, S Vergeiner… - Dalton …, 2016 - pubs.rsc.org
A cobaltoceniumethynyl gold (I) complex with a triphenylphosphane ligand triggered
efficient cytotoxic effects in cancer cells in contrast to a derivative with two cobaltocenium …
efficient cytotoxic effects in cancer cells in contrast to a derivative with two cobaltocenium …
Novel antitumor adamantane–azole gold (I) complexes as potential inhibitors of thioredoxin reductase
A Garcia, RC Machado, RM Grazul, MTP Lopes… - JBIC Journal of …, 2016 - Springer
Gold complexes that could act as antitumor agents have attracted great attention.
Heterocyclic compounds and their metal complexes display a broad spectrum of …
Heterocyclic compounds and their metal complexes display a broad spectrum of …