Prion diseases are a group of neurodegenerative disorders associated with the
conformational conversion of the cellular prion protein (PrP C) into an abnormal misfolded …

The discovery of prions has challenged dogmas and has revolutionized our understanding
of protein‐misfolding diseases. The concept of self‐propagation via protein conformational …

The precise molecular mechanism of how misfolded α-synuclein (α-Syn) accumulates and
spreads in synucleinopathies is still unknown. Here, we show the role of the cellular prion …

The cellular prion protein, PrPC, has been postulated to function as a receptor for α-
synuclein, potentially facilitating cell-to-cell spreading and/or toxicity of α-synuclein …

For more than a decade, the “prion-like” hypothesis for Parkinson's disease (PD) has
remained one of the most controversial topics in neurodegenerative disease research [21 …

Prion related disorders are associated with the accumulation of a misfolded isoform (PrPsc)
of the host-encoded prion protein, PrP. There is strong evidence for the involvement of …

Synucleinopathies are a group of neurodegenerative diseases characterized by the
accumulation of α-synuclein amyloids in several regions of the brain. α-Synuclein fibrils are …

The cellular prion protein, encoded by the gene Prnp, has been reported to be a receptor of
β-amyloid. Their interaction is mandatory for neurotoxic effects of β-amyloid oligomers. In …

The term 'prion-like'is used to define some misfolded protein species that propagate
intercellularly, triggering protein aggregation in recipient cells. For cell binding, both direct …

Prion disease (PrD) and Parkinson's disease (PD) are neurodegenerative diseases
characterized by aggregation of misfolded proteins in brain tissues, including protease …