Pathological remodeling of the extracellular matrix (ECM) by fibroblasts leads to organ
failure. Development of idiopathic pulmonary fibrosis (IPF) is characterized by a progressive …

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disorder driven by
unrelenting extracellular matrix deposition. Fibroblasts are recognized as the central …

The extracellular matrix (ECM) is dynamically tuned to optimize physiological function. Its
major properties, including composition and mechanics, profoundly influence cell biology …

Pulmonary fibrosis (PF) is a form of chronic lung disease characterized by pathologic
epithelial remodeling and accumulation of extracellular matrix (ECM). To comprehensively …

Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic disease of the lung that is marked by
progressive decline in pulmonary function and ultimately respiratory failure. Genetic and …

Progressive pulmonary fibrosis results from a dysfunctional tissue repair response and is
characterized by fibroblast proliferation, activation, and invasion and extracellular matrix …

The extracellular matrix (ECM) in idiopathic pulmonary fibrosis (IPF) drives fibrosis
progression; however, the ECM composition of the fibroblastic focus (the hallmark lesion in …

Idiopathic pulmonary fibrosis (IPF) is a chronic disease of unmet medical need. It is
characterized by formation of scar tissue leading to a progressive and irreversible decline in …

Repairing damaged tissues is an essential homeostatic mechanism that enables clearance
of dead or damaged cells after injury, and the maintenance of tissue integrity. However …

Pulmonary fibrosis and emphysema are chronic lung diseases characterized by a
progressive decline in lung function, resulting in significant morbidity and mortality. A …