Pulmonary fibrosis: a cellular overreaction or a failure of communication?
D Sheppard - The Journal of Clinical Investigation, 2001 - Am Soc Clin Investig
See related article, pages 1529–1536. that a central feature is a network of reciprocal
inductive and inhibitory signals involving at least mesenchymal cells, pulmonary epithelial …
inductive and inhibitory signals involving at least mesenchymal cells, pulmonary epithelial …
Integrating mechanisms of pulmonary fibrosis
TA Wynn - Journal of Experimental Medicine, 2011 - rupress.org
Pulmonary fibrosis is a highly heterogeneous and lethal pathological process with limited
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …
therapeutic options. Although research on the pathogenesis of pulmonary fibrosis has …
Pulmonary fibrosis requires cell-autonomous mesenchymal fibroblast growth factor (FGF) signaling
RD Guzy, L Li, C Smith, SJ Dorry, HY Koo… - Journal of Biological …, 2017 - ASBMB
Idiopathic pulmonary fibrosis (IPF) is characterized by progressive pulmonary scarring,
decline in lung function, and often results in death within 3–5 five years after diagnosis …
decline in lung function, and often results in death within 3–5 five years after diagnosis …
Idiopathic pulmonary fibrosis: from epithelial injury to biomarkers-insights from the bench side
M Kolb, K Borensztajn, B Crestani, M Kolb - Respiration, 2014 - karger.com
Idiopathic pulmonary fibrosis (IPF) is the most frequent fibrotic diffuse parenchymal lung
disease. Its prognosis is devastating:> 50% of the patients die within 3 years after diagnosis …
disease. Its prognosis is devastating:> 50% of the patients die within 3 years after diagnosis …
Matrix abnormalities in pulmonary fibrosis
C Upagupta, C Shimbori, R Alsilmi… - European Respiratory …, 2018 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a devastating, progressive disease, marked by
excessive scarring, which leads to increased tissue stiffness, loss in lung function and …
excessive scarring, which leads to increased tissue stiffness, loss in lung function and …
MicroRNA regulatory networks in idiopathic pulmonary fibrosis
KV Pandit, J Milosevic - Biochemistry and Cell Biology, 2015 - cdnsciencepub.com
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and fatal scarring lung disease
of unknown etiology, characterized by changes in microRNA expression. Activation of …
of unknown etiology, characterized by changes in microRNA expression. Activation of …
Unravelling the progressive pathophysiology of idiopathic pulmonary fibrosis
A Günther, M Korfei, P Mahavadi… - European …, 2012 - Eur Respiratory Soc
Idiopathic pulmonary fibrosis (IPF) is a life-threatening condition, with a median survival of<
3 yrs. The pathophysiology is not fully understood, but chronic injury of alveolar epithelial …
3 yrs. The pathophysiology is not fully understood, but chronic injury of alveolar epithelial …
Regional and disease specific human lung extracellular matrix composition
ET Hoffman, FE Uhl, L Asarian, B Deng, C Becker… - Biomaterials, 2023 - Elsevier
Chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and
idiopathic pulmonary fibrosis (IPF), are characterized by regional extracellular matrix (ECM) …
idiopathic pulmonary fibrosis (IPF), are characterized by regional extracellular matrix (ECM) …
Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation
AJ Booth, R Hadley, AM Cornett, AA Dreffs… - American journal of …, 2012 - atsjournals.org
Rationale: Extracellular matrix (ECM) is a dynamic tissue that contributes to organ integrity
and function, and its regulation of cell phenotype is a major aspect of cell biology. However …
and function, and its regulation of cell phenotype is a major aspect of cell biology. However …
Ex vivo tissue perturbations coupled to single-cell RNA-seq reveal multilineage cell circuit dynamics in human lung fibrogenesis
NJ Lang, J Gote-Schniering… - Science translational …, 2023 - science.org
Pulmonary fibrosis develops as a consequence of failed regeneration after injury. Analyzing
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …
mechanisms of regeneration and fibrogenesis directly in human tissue has been hampered …