Idiopathic pulmonary fibrosis (IPF) is an aggressive disease in which normal lung
parenchyma is replaced by a stiff dysfunctional scar rich in activated fibroblasts and collagen …

Idiopathic pulmonary fibrosis (IPF) is a relentlessly progressive and devastating interstitial
lung disease of unknown etiology, where the normal lung architecture is lost and replaced …

Lung epithelial cells have emerged as a frequent target of injury, a driver of normal repair,
and a key element in the pathobiology of fibrotic lung diseases. An important aspect of …

Idiopathic pulmonary fibrosis is a disease of older adults leading to progressive dyspnea
and reduced exercise capacity, typically resulting in death within 3-5years of diagnosis …

Pulmonary fibrosis is a relatively rare but devastating disease characterized by the
excessive deposition of extracellular matrix. The increased matrix results in reduced lung …

To develop a systems biology model of fibrosis progression within the human lung we
performed RNA sequencing and microRNA analysis on 95 samples obtained from 10 …

Fibrosis is the excessive accumulation of extracellular matrix that often occurs as a wound
healing response to repeated or chronic tissue injury, and may lead to the disruption of …

The activation of fibroblasts is required for physiological tissue remodelling such as wound
healing. However, when the regulatory mechanisms are disrupted and fibroblasts remain …

Fibrosis is a chronic and progressive disorder characterized by excessive deposition of
extracellular matrix, which leads to scarring and loss of function of the affected organ or …

Fibrosis is a pervasive disease in which the excessive deposition of extracellular matrix
(ECM) compromises tissue function. Although the underlying mechanisms are mostly …