Colorectal cancer (CRC) is one of the most common cancers and one of the leading causes
of cancer related deaths worldwide. CRC is a heterogeneous disease where there can be …

A number of successful systemic therapies are available for the treatment of disseminated
cancers. However, tumor response is often transient, and therapy frequently fails due to …

Simple Summary Chemotherapy, radiotherapy and molecularly targeted therapy could
improve the prognosis of colorectal cancer (CRC) patients. Recently, immunotherapy …

Colorectal cancer (CRC) remains one of the most diagnosed and fatal cancers in China and
worldwide, bringing clinical and economic burdens. Despite recent improvements in …

Resistance to chemotherapy limits the effectiveness of current cancer therapies, including
those used to treat colorectal cancer, which is the second most common cause of cancer …

Colorectal cancer (CRC) remains the third most common cause of cancer-related deaths in
both men and women worldwide. Despite recent advances in clinical practice and effective …

Drug Resistance in Colorectal Cancer: Molecular Mechanisms and Therapeutic Strategies,
Volume Eight, summarizes the molecular mechanisms of drug resistance in colorectal …

Current standard treatments for metastatic colorectal cancer (CRC) are based on
combination regimens with one of the two chemotherapeutic drugs, irinotecan or oxaliplatin …

Despite the continuous deployment of advanced treatment strategies, most disseminated
cancers remain fatal. Like species evolution, cancer is subject to the evolutionary processes …

Cancer resistance evolution was presumed to result from either a pre-existing or acquired
mutation that survives treatment, re-populating the tumour following therapy. However, it …