Methylation regulation of Antiviral host factors, Interferon Stimulated Genes (ISGs) and T-cell responses associated with natural HIV control
B Oriol-Tordera, M Berdasco, A Llano, B Mothe… - PLoS …, 2020 - journals.plos.org
GWAS, immune analyses and biomarker screenings have identified host factors associated
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …
with in vivo HIV-1 control. However, there is a gap in the knowledge about the mechanisms …
Deciphering DNA methylation in HIV infection
T Arumugam, U Ramphal, T Adimulam… - Frontiers in …, 2021 - frontiersin.org
With approximately 38 million people living with HIV/AIDS globally, and a further 1.5 million
new global infections per year, it is imperative that we advance our understanding of all …
new global infections per year, it is imperative that we advance our understanding of all …
Effect of HIV infection and antiretroviral therapy initiation on genome-wide DNA methylation patterns
A Esteban-Cantos, J Rodríguez-Centeno, JC Silla… - …, 2023 - thelancet.com
Background Previous epigenome-wide association studies have shown that HIV infection
can disrupt the host DNA methylation landscape. However, it remains unclear how …
can disrupt the host DNA methylation landscape. However, it remains unclear how …
Epigenome-wide differential DNA methylation between HIV-infected and uninfected individuals
Epigenetic control of human immunodeficiency virus-1 (HIV-1) genes is critical for viral
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
integration and latency. However, epigenetic changes in the HIV-1-infected host genome …
The Genome-wide Methylation Profile of CD4+ T Cells From Individuals With Human Immunodeficiency Virus (HIV) Identifies Distinct Patterns Associated With …
S Moron-Lopez, V Urrea, J Dalmau… - Clinical Infectious …, 2021 - academic.oup.com
Background Human genetic variation—mostly in the human leukocyte antigen (HLA) and C–
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …
C chemokine receptor type 5 (CCR5) regions—explains 25% of the variability in progression …
Abrupt and altered cell-type specific DNA methylation profiles in blood during acute HIV infection persists despite prompt initiation of ART
MJ Corley, C Sacdalan, APS Pang, N Chomchey… - PLoS …, 2021 - journals.plos.org
HIV-1 disrupts the host epigenetic landscape with consequences for disease pathogenesis,
viral persistence, and HIV-associated comorbidities. Here, we examined how soon after …
viral persistence, and HIV-associated comorbidities. Here, we examined how soon after …
HIV infection alters the human epigenetic landscape
Many complex diseases or traits are the results of both genetic and environmental factors.
The environmental factors affect the human body by modifying its epigenetics, which …
The environmental factors affect the human body by modifying its epigenetics, which …
DNA methylation changes in metabolic and immune-regulatory pathways in blood and lymph node CD4+ T cells in response to SIV infections
The molecular mechanisms underlying HIV-induced inflammation, which persists even
during effective long-term treatment, remain incompletely defined. Here, we studied …
during effective long-term treatment, remain incompletely defined. Here, we studied …
Methylation: a regulator of HIV-1 replication?
VRK Yedavalli, KT Jeang - Retrovirology, 2007 - Springer
Recent characterizations of methyl transferases as regulators of cellular processes have
spurred investigations into how methylation events might influence the HIV-1 life cycle …
spurred investigations into how methylation events might influence the HIV-1 life cycle …
HIV Modifies the m6A and m5C Epitranscriptomic Landscape of the Host Cell
S Cristinelli, P Angelino, A Janowczyk… - Frontiers in …, 2021 - frontiersin.org
The study of RNA modifications, today known as epitranscriptomics, is of growing interest.
The N6-methyladenosine (m6A) and 5-methylcytosine (m5C) RNA modifications are …
The N6-methyladenosine (m6A) and 5-methylcytosine (m5C) RNA modifications are …