Circulating dipeptidyl peptidase 3 and bio-adrenomedullin levels are associated with impaired outcomes in critically ill COVID-19 patients: a prospective international …

D van Lier, B Deniau, K Santos, O Hartmann… - ERJ Open …, 2023 - Eur Respiratory Soc
Introduction Dipeptidyl peptidase-3 (DPP3) is a protease involved in the degradation of
several cardiovascular mediators. Adrenomedullin (bio-ADM) is a peptide essential for …

Plasma bioactive adrenomedullin predicts mortality and need for dialysis in critical COVID-19

P Johnsson, T Sievert, I Didriksson, H Friberg… - Scientific Reports, 2024 - nature.com
COVID-19 is a severe respiratory disease affecting millions worldwide, causing significant
morbidity and mortality. Adrenomedullin (bio-ADM) is a vasoactive hormone regulating the …

Bioactive adrenomedullin and interleukin-6 in COVID-19: potential biomarkers of acute kidney injury and critical illness

SB Leininger, ST Staudner, MJ Vogel, J Mustroph… - BMC nephrology, 2024 - Springer
Background The aim of this study was to investigate whether bioactive adrenomedullin (bio-
ADM) and interleukin-6 (IL-6) are related to acute kidney injury (AKI) and severe illness in …

Utility of Measuring Circulating Bio-Adrenomedullin and Proenkephalin for 30-Day Mortality Risk Prediction in Patients with COVID-19 and Non-COVID-19 Interstitial …

ID Papasidero, G Valli, D Marin, A Del Sasso… - Medicina, 2022 - mdpi.com
Background and Objectives: In order to accelerate the risk stratification of patients referred to
the Emergency Department (ED) with interstitial pneumonia, it could be useful to provide …

Prognostic value of bioactive adrenomedullin in critically ill patients with COVID-19 in Germany: an observational cohort study

TP Simon, C Stoppe, T Breuer, L Stiehler… - Journal of Clinical …, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic has placed a significant burden on
hospitals worldwide. Objective biomarkers for early risk stratification and clinical …

Effectiveness of mid-regional pro-adrenomedullin, compared to other biomarkers (including lymphocyte subpopulations and immunoglobulins), as a prognostic …

G Montrucchio, G Sales, E Balzani, D Lombardo… - Frontiers in …, 2023 - frontiersin.org
Background Mid-regional pro-adrenomedullin (MR-proADM), an endothelium-related
peptide, is a predictor of death and multi-organ failure in respiratory infections and sepsis …

Decreased circulating dipeptidyl peptidase-4 enzyme activity is prognostic for severe outcomes in COVID-19 inpatients

A Nadasdi, G Sinkovits, I Bobek, B Lakatos… - Biomarkers in …, 2022 - Taylor & Francis
Aim: To investigate the serum circulating DPP4 activity in patients with COVID-19 disease.
Materials & methods: Serum samples from 102 hospitalized COVID-19 patients and 43 post …

Endothelial dysfunction and mid-regional proadrenomedullin: what role in SARS-CoV-2 infected patients?

M Zaninotto, MM Mion, L Marchioro, A Padoan… - Clinica Chimica …, 2021 - Elsevier
Background Endothelial dysfunction, a major complication of SARS-CoV-2 infectionplaying
a key-role in multi-organ damage, carries high risk of mortality. Aim To investigate the …

Effectiveness of mid-regional pro-adrenomedullin (MR-proADM) as prognostic marker in COVID-19 critically ill patients: An observational prospective study

G Montrucchio, G Sales, F Rumbolo, F Palmesino… - PLoS …, 2021 - journals.plos.org
Objective To test the effectiveness of mid-regional pro-adrenomedullin (MR-proADM) in
comparison to C-reactive protein (CRP), procalcitonin (PCT), D-dimer, lactate …

High value of mid‐regional proadrenomedullin in COVID‐19: A marker of widespread endothelial damage, disease severity, and mortality

S Spoto, FE Agrò, F Sambuco… - Journal of Medical …, 2021 - Wiley Online Library
The widespread endothelial damage due to severe acute respiratory syndrome coronavirus
2 (SARS‐CoV‐2) may lead to a disruption of the adrenomedullin (ADM) system responsible …