Fis contributes to resistance of Pseudomonas aeruginosa to ciprofloxacin by regulating pyocin synthesis

Y Long, W Fu, S Wang, X Deng, Y Jin, F Bai… - Journal of …, 2020 - Am Soc Microbiol
Factor for inversion stimulation (Fis) is a versatile DNA binding protein that plays an
important role in coordinating bacterial global gene expression in response to growth …

Ciprofloxacin Induction of a Susceptibility Determinant in Pseudomonas aeruginosa

MD Brazas, REW Hancock - Antimicrobial agents and …, 2005 - Am Soc Microbiol
With few novel antimicrobials in development, resistance to the current selection of
antibiotics increasingly encroaches on our ability to control microbial infections. One …

[HTML][HTML] Pseudomonas aeruginosa Polynucleotide Phosphorylase Contributes to Ciprofloxacin Resistance by Regulating PrtR

Z Fan, H Chen, M Li, X Pan, W Fu, H Ren… - Frontiers in …, 2019 - frontiersin.org
Pseudomonas aeruginosa is an opportunistic bacterial pathogen that causes various acute
and chronic infections. It is intrinsically resistant to a variety of antibiotics. However …

PrtR homeostasis contributes to Pseudomonas aeruginosa pathogenesis and resistance against ciprofloxacin

Z Sun, J Shi, C Liu, Y Jin, K Li, R Chen, S Jin… - Infection and …, 2014 - Am Soc Microbiol
Pseudomonas aeruginosa is an opportunistic pathogen that causes acute and chronic
infections in humans. Pyocins are bacteriocins produced by P. aeruginosa that are usually …

Pseudomonas aeruginosa oligoribonuclease contributes to tolerance to ciprofloxacin by regulating pyocin biosynthesis

F Chen, G Chen, Y Liu, Y Jin, Z Cheng… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
Bacterial oligoribonuclease (Orn) is a conserved 3′-to-5′ exonuclease. In Pseudomonas
aeruginosa, it has been demonstrated that Orn plays a major role in the hydrolysis of pGpG …

Mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa: new approaches to an old problem

A Rehman, WM Patrick… - Journal of Medical …, 2019 - microbiologyresearch.org
The antibiotic ciprofloxacin is used extensively to treat a wide range of infections caused by
the opportunistic pathogen Pseudomonas aeruginosa. Due to its extensive use, the …

Pseudomonas aeruginosa develops Ciprofloxacin resistance from low to high level with distinctive proteome changes

J Peng, J Cao, FM Ng, J Hill - Journal of proteomics, 2017 - Elsevier
Pseudomonas aeruginosa infection is difficult to treat because of its drug resistance, but how
it develops drug resistance remains largely unknown. In this study we investigated …

[HTML][HTML] A role for the stringent response in ciprofloxacin resistance in Pseudomonas aeruginosa

L García-Villada, NP Degtyareva, AM Brooks… - Scientific Reports, 2024 - nature.com
Pseudomonas aeruginosa is a major cause of nosocomial infections and the leading cause
of chronic lung infections in cystic fibrosis and chronic obstructive pulmonary disease …

[HTML][HTML] Mechanisms for Development of Ciprofloxacin Resistance in a Clinical Isolate of Pseudomonas aeruginosa

C Xu, H Liu, X Pan, Z Ma, D Wang, X Zhang… - Frontiers in …, 2021 - frontiersin.org
Treatment of infections by Pseudomonas aeruginosa is difficult due to its high intrinsic and
acquired antibiotic resistance. Upon colonization in the human hosts, P. aeruginosa …

[HTML][HTML] Fis Regulates Type III Secretion System by Influencing the Transcription of exsA in Pseudomonas aeruginosa Strain PA14

X Deng, M Li, X Pan, R Zheng, C Liu, F Chen… - Frontiers in …, 2017 - frontiersin.org
Fis is a versatile DNA binding protein in bacteria. It has been demonstrated in multiple
bacteria that Fis plays crucial roles in regulating bacterial virulence factors and optimizing …