Protein export through the bacterial Sec pathway

A Tsirigotaki, J De Geyter, A Economou… - Nature Reviews …, 2017 - nature.com
The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Following the leader: bacterial protein export through the Sec pathway

A Economou - Trends in Microbiology, 1999 - cell.com
Significant strides have been made during the past 20 years in our understanding of protein
secretion across the bacterial inner membrane. Specialized chaperones select secretory …

Breaking on through to the other side: protein export through the bacterial Sec system

KE Chatzi, MF Sardis, S Karamanou… - Biochemical …, 2013 - portlandpress.com
More than one-third of cellular proteomes traffic into and across membranes. Bacteria have
invented several sophisticated secretion systems that guide various proteins to …

The Sec translocon mediated protein transport in prokaryotes and eukaryotes

K Denks, A Vogt, I Sachelaru, NA Petriman… - Molecular membrane …, 2014 - Taylor & Francis
Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

Protein translocation across the bacterial cytoplasmic membrane

AJM Driessen, N Nouwen - Annu. Rev. Biochem., 2008 - annualreviews.org
About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …

The bacterial translocase: a dynamic protein channel complex

J De Keyzer, C Van Der Does… - Cellular and Molecular Life …, 2003 - Springer
The major route of protein translocation in bacteria is the so-called general secretion
pathway (Sec-pathway). This route has been extensively studied in Escherichia coli and …

Structure of the SecY complex unlocked by a preprotein mimic

D Hizlan, A Robson, S Whitehouse, VA Gold, J Vonck… - Cell reports, 2012 - cell.com
The Sec complex forms the core of a conserved machinery coordinating the passage of
proteins across or into biological membranes. The bacterial complex SecYEG interacts with …

Mechanisms of Sec61/SecY-mediated protein translocation across membranes

E Park, TA Rapoport - Annual review of biophysics, 2012 - annualreviews.org
The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …

The Sec System: Protein Export in Escherichia coli

JM Crane, LL Randall - EcoSal Plus, 2017 - Am Soc Microbiol
In Escherichia coli, proteins found in the periplasm or the outer membrane are exported from
the cytoplasm by the general secretory, Sec, system before they acquire stably folded …

[HTML][HTML] The Sec-dependent pathway

J Beckwith - Research in microbiology, 2013 - Elsevier
The Sec pathway for export of proteins across the cytoplasmic membrane to the bacterial
periplasm and outer membrane was the first secretion pathway to be discovered in bacteria …