The general secretory (Sec) pathway comprises an essential, ubiquitous and universal
export machinery for most proteins that integrate into, or translocate through, the plasma …

Significant strides have been made during the past 20 years in our understanding of protein
secretion across the bacterial inner membrane. Specialized chaperones select secretory …

More than one-third of cellular proteomes traffic into and across membranes. Bacteria have
invented several sophisticated secretion systems that guide various proteins to …

Protein transport via the Sec translocon represents an evolutionary conserved mechanism
for delivering cytosolically-synthesized proteins to extra-cytosolic compartments. The Sec …

About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …

The major route of protein translocation in bacteria is the so-called general secretion
pathway (Sec-pathway). This route has been extensively studied in Escherichia coli and …

The Sec complex forms the core of a conserved machinery coordinating the passage of
proteins across or into biological membranes. The bacterial complex SecYEG interacts with …

The Sec61 or SecY channel, a universally conserved protein-conducting channel,
translocates proteins across and integrates proteins into the eukaryotic endoplasmic …

In Escherichia coli, proteins found in the periplasm or the outer membrane are exported from
the cytoplasm by the general secretory, Sec, system before they acquire stably folded …

Protein translocation across the bacterial membrane, mediated by the secretory translocon
SecYEG and the SecA ATPase,,,, is enhanced by proton motive force, and membrane …