Rapid and selective apoptosis in human leukemic cells induced by Aplidine through a Fas/CD95-and mitochondrial-mediated mechanism
C Gajate, F An, F Mollinedo - Clinical cancer research, 2003 - AACR
Aplidine is a promising antitumor agent derived from the Mediterranean tunicate Aplidium
albicans. We have found that Aplidine at nm concentrations (10–100 nm) induced apoptosis …
albicans. We have found that Aplidine at nm concentrations (10–100 nm) induced apoptosis …
Induction of apoptosis by apicidin, a histone deacetylase inhibitor, via the activation of mitochondria-dependent caspase cascades in human Bcr-Abl-positive leukemia …
JW Cheong, SY Chong, JY Kim, JI Eom, HK Jeung… - Clinical Cancer …, 2003 - AACR
Purpose: Apicidin, a histone deacetylase inhibitor, is a novel cyclic tetrapeptide that exhibits
potent antiproliferative activity against various cancer cell lines. The aim of this study was to …
potent antiproliferative activity against various cancer cell lines. The aim of this study was to …
Apigeninidin induces apoptosis through activation of Bak and Bax and subsequent mediation of mitochondrial damage in human promyelocytic leukemia HL-60 cells
HJ Woo, IT Oh, JY Lee, MC Seu, KS Woo, MH Nam… - Process …, 2012 - Elsevier
Treatment of human promyelocytic leukemia HL-60 cells with apigeninidin could induce
cytotoxicity (IC50=∼ 80μM), along with apoptotic sub-G1 cells, TUNEL-positive apoptotic …
cytotoxicity (IC50=∼ 80μM), along with apoptotic sub-G1 cells, TUNEL-positive apoptotic …
The effect of apigenin and chemotherapy combination treatments on apoptosis-related genes and proteins in acute leukaemia cell lines
Apigenin is a dietary polyphenol found abundantly in fruit and vegetables, which sensitizes
leukaemia cells to topoisomerase inhibitor agents (eg, etoposide), and alkylating agents (eg …
leukaemia cells to topoisomerase inhibitor agents (eg, etoposide), and alkylating agents (eg …
Adenine deoxynucleotides fludarabine and cladribine induce apoptosis in a CD95/Fas receptor, FADD and caspase-8-independent manner by activation of the …
A Klöpfer, A Hasenjäger, C Belka, K Schulze-Osthoff… - Oncogene, 2004 - nature.com
The adenine deoxynucleosides cladribine (2CdA) and fludarabine (FAraA) are DNA-
damaging agents that interfere with DNA repair and induce apoptosis in nonproliferating …
damaging agents that interfere with DNA repair and induce apoptosis in nonproliferating …
2-Chloro-2'-deoxyadenosine-induced apoptosis in T leukemia cells is mediated via a caspase-3-dependent mitochondrial feedback amplification loop
DM Conrad, MRJ Robichaud… - International …, 2008 - spandidos-publications.com
Chloro-2'-deoxyadenosine (CdA; cladribine) is a chemotherapeutic agent used in the
treatment of certain leukemias. However, the signalling events that govern CdA-mediated …
treatment of certain leukemias. However, the signalling events that govern CdA-mediated …
Role of caspases and apoptosis-inducing factor (AIF) in cladribine-induced apoptosis of B cell chronic lymphocytic leukemia
P Perez-Galan, I Marzo, P Giraldo, D Rubio-Felix… - Leukemia, 2002 - nature.com
We have evaluated the role of caspases and the mitochondrial apoptosis inducing-factor
(AIF) in apoptosis induced by cladribine (2CdA), in vitro, in cells from patients of B-CLL and …
(AIF) in apoptosis induced by cladribine (2CdA), in vitro, in cells from patients of B-CLL and …
Cladribine induces apoptosis in human leukaemia cells by caspase-dependent and-independent pathways acting on mitochondria
I Marzo, P PÉREZ-GALÁN, P GIRALDO… - Biochemical …, 2001 - portlandpress.com
We have studied the role of caspases and mitochondria in apoptosis induced by 2-chloro-
2′-deoxyadenosine (cladribine) in several human leukaemic cell lines. Cladribine …
2′-deoxyadenosine (cladribine) in several human leukaemic cell lines. Cladribine …
Induction of apoptosis by apigenin and related flavonoids through cytochrome c release and activation of caspase-9 and caspase-3 in leukaemia HL-60 cells
IK Wang, SY Lin-Shiau, JK Lin - European journal of cancer, 1999 - Elsevier
The aim of this study was to investigate the mechanism of flavonoid-induced apoptosis in HL-
60 leukaemic cells. Thus, the effect of structurally related flavonoids on cell viability, DNA …
60 leukaemic cells. Thus, the effect of structurally related flavonoids on cell viability, DNA …
Apicidin, a histone deacetylase inhibitor, induces apoptosis and Fas/Fas ligand expression in human acute promyelocytic leukemia cells
We previously reported that apicidin arrested human cancer cell growth through selective
induction of p21 WAF1/Cip1. In this study, the apoptotic potential of apicidin and its …
induction of p21 WAF1/Cip1. In this study, the apoptotic potential of apicidin and its …