Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the
central nervous system (CNS) affecting more than two million people worldwide. In MS …

Background With millions of victims worldwide, multiple sclerosis is the second most
common cause of disability among young adults. Although formidable advancements have …

Remyelination failure plays an important role in the pathophysiology of multiple sclerosis,
but the underlying cellular and molecular mechanisms remain poorly understood. We now …

Chronic demyelination is a pathological hallmark of multiple sclerosis (MS). Only a minority
of MS lesions remyelinates completely. Enhancing remyelination is, therefore, a major aim of …

Abstract Fibroblast growth factor 2 (FGF2) is an excellent candidate to regulate
remyelination based on its proposed actions in oligodendrocyte lineage cell development in …

The role of fibroblast growth factor‐2 (FGF‐2) in multiple sclerosis and its animal model
experimental autoimmune encephalomyelitis is discussed. This study is the first to use FGF …

This study takes advantage of fibroblast growth factor 2 (FGF2) knock-out mice to determine
the contribution of FGF2 to the regeneration of oligodendrocytes in the adult CNS. The role …

Fibroblast growth factors (FGFs) exert diverse biological effects by binding and activation of
specific fibroblast growth factor receptors (FGFRs). FGFs and FGFRs have been implicated …

Oligodendrocytes are the myelin-forming cells of the CNS and are lost in demyelinating
diseases such as multiple sclerosis (MS). A role for fibroblast growth factor 2 (FGF2) has …

Remyelination is a potent regenerative process in demyelinating diseases, such as multiple
sclerosis, the effective therapeutic promotion of which will fill an unmet clinical need. The …