Preclinical studies of erythropoietin receptor expression in tumour cells: impact on clinical use of erythropoietic proteins to correct cancer-related anaemia
A Österborg, M Aapro, P Cornes, A Haselbeck… - European Journal of …, 2007 - Elsevier
In vitro and animal model studies have shown erythropoietin receptor (Epo-R) mRNA and/or
protein may be present in a range of human tumours and cancer cell lines, and …
protein may be present in a range of human tumours and cancer cell lines, and …
Expression and function of erythropoietin receptors in tumors: Implications for the use of erythropoiesis‐stimulating agents in cancer patients
AM Sinclair, MD Todd, K Forsythe… - … Journal of the …, 2007 - Wiley Online Library
Safety concerns surrounding the use of recombinant human erythropoietin (Epo) to treat
anemia in cancer patients were raised after 2 recent clinical studies reported a worse …
anemia in cancer patients were raised after 2 recent clinical studies reported a worse …
Erythropoietin receptors on tumor cells: what do they mean?
J Fandrey - The Oncologist, 2008 - academic.oup.com
Given the apparent presence of erythropoietin receptors (EPORs) in cancer tissues,
questions have been raised about the possible influence of erythropoiesis-stimulating …
questions have been raised about the possible influence of erythropoiesis-stimulating …
The role of erythropoietin and its receptor in growth, survival and therapeutic response of human tumor cells: from clinic to bench—a critical review
J Szenajch, G Wcislo, JY Jeong, C Szczylik… - … et Biophysica Acta (BBA …, 2010 - Elsevier
Recombinant human erythropoietin (rhEPO) has been used clinically to alleviate cancer-and
chemotherapy-related anemia. However, recent clinical trials have reported that rhEPO also …
chemotherapy-related anemia. However, recent clinical trials have reported that rhEPO also …
The erythropoietin receptor
L Mulcahy - Seminars in oncology, 2001 - Elsevier
Erythropoietin (EPO) is the primary regulator of erythropoiesis, and promotes the survival,
proliferation, and differentiation of erythroid progenitor cells. The EPO receptor belongs to …
proliferation, and differentiation of erythroid progenitor cells. The EPO receptor belongs to …
Lack of functional erythropoietin receptors of cancer cell lines
M Laugsch, E Metzen, T Svensson… - … journal of cancer, 2008 - Wiley Online Library
Erythropoietin (Epo) therapy reduces red cell transfusion requirements and improves the
quality of life of anemic cancer patients receiving chemotherapy. However, there is concern …
quality of life of anemic cancer patients receiving chemotherapy. However, there is concern …
Expression of Erythropoietin Receptor and In vitro Functional Effects of Epoetins in B-Cell Malignancies
P Kokhaei, AO Abdalla, L Hansson, E Mikaelsson… - Clinical cancer …, 2007 - AACR
Abstract Purpose: Erythropoietin (EPO) and EPO receptor (EPO-R) expression have been
reported in solid tumors and are claimed to regulate tumor growth; however, no data have …
reported in solid tumors and are claimed to regulate tumor growth; however, no data have …
The effect of erythropoietin on normal and neoplastic cells
S Elliott, AM Sinclair - Biologics: Targets and Therapy, 2012 - Taylor & Francis
Erythropoietin (Epo) is an essential hormone that binds and activates the Epo receptor
(EpoR) resident on the surface of erythroid progenitor cells, thereby promoting …
(EpoR) resident on the surface of erythroid progenitor cells, thereby promoting …
Characterization of erythropoietin receptor and erythropoietin expression and function in human ovarian cancer cells
JY Jeong, L Feldman, P Solar… - … journal of cancer, 2008 - Wiley Online Library
The identification of erythropoietin receptors (EpoR) on cancer cells has caused concern,
since it implies the possibility that treatment of cancer patients with erythropoietin (Epo) and …
since it implies the possibility that treatment of cancer patients with erythropoietin (Epo) and …
The erythropoietin receptor in normal and cancer tissues
The hormone erythropoietin (EPO) is essential for the survival, proliferation and
differentiation of the erythrocytic progenitors. The EPO receptor (EPO-R) of erythrocytic cells …
differentiation of the erythrocytic progenitors. The EPO receptor (EPO-R) of erythrocytic cells …
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