Opioid and its receptors play important roles in glucose homeostasis. However, few reports
were available for the study of κ‐opioid receptor in glucose regulation. In our study, we …

Objective Fructose feeding induces hypertension, insulin-resistance and
hypertriglyceridemia in Sprague-Dawley rats. The mechanisms of fructose-induced …

We aimed to determine whether acute treatment with candesartan cilexetil (CV-11974), an
angiotensin II type 1 receptor blocker (ARB) can improve insulin sensitivity in high-fructose …

Abstract Diabetes mellitus type 2 (DM2) is a disease with increasing importance in modern
societies and insufficient treatment options. Pharmacological stimulation of insulin signaling …

Aims This study examined whether chronic treatment with losartan, an angiotensin II type 1
receptor (AT 1 R) antagonist, might reverse COX-2-mediated vascular dysfunction in …

Many clinical and experimental studies have suggested that diabetes or hyperglycemia alter
pain sensitivity, and sensitivity to several drugs. It has been reported that the antinociceptive …

Diabetes and hypertension have been associated with cardiovascular diseases and stroke.
Some reports have related the coexistence of hypertension and diabetes with increase in …

Background—ACE inhibitors (ACEIs) improve insulin resistance and prevent type 2
diabetes, possibly mediated by inhibition of bradykinin (BK) degradation. The vasopeptidase …

Diosmin is one of the flavonoids contained in citrus and has been demonstrated to improve
glucose metabolism in diabetic disorders. However, the mechanism (s) of diosmin in …

Absolute or relative hyperglucagonemia is often a feature of type 1 and type 2 diabetes
mellitus. The suppression of excessive glucagon secretion has been proposed as a …