Molecular mechanisms of antiproliferative effects of natural chalcones

R Michalkova, L Mirossay, M Gazdova, M Kello… - Cancers, 2021 - mdpi.com
Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …

Anticancer potential of natural chalcones: in vitro and in vivo evidence

R Michalkova, L Mirossay, M Kello… - International Journal of …, 2023 - mdpi.com
There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Recent progresses in chalcone derivatives as potential anticancer agents

J Yang, J Lv, S Cheng, T Jing, T Meng… - Anti-Cancer Agents …, 2023 - ingentaconnect.com
Chalcones are members of the flavonoid family and act as intermediates in the biosynthesis
of flavonoids, which are widespread in plants. Meanwhile, chalcones are important …

Chalcones against the hallmarks of cancer: A mini-review

PS de Souza, GCC Bibá, EDN Melo… - Natural Product …, 2021 - Taylor & Francis
Abstract Chalcones (1, 3-diphenylpropen-1-ones) are a class of flavonoids that have been
shown a broad spectrum of biological activities with therapeutic potential. Naturally …

Chalcone scaffolds as anticancer drugs: a review on molecular insight in action of mechanisms and anticancer properties

S Shukla, AK Sood, K Goyal, A Singh… - Anti-Cancer Agents …, 2021 - ingentaconnect.com
Cancer is the deadliest disease worldwide and the development of safer chemical entities to
treat cancer is one of the major challenges of medicinal chemistry. The emergence of new …

Pharmacological properties of chalcones: a review of preclinical including molecular mechanisms and clinical evidence

B Salehi, C Quispe, I Chamkhi, N El Omari… - Frontiers in …, 2021 - frontiersin.org
Chalcones are among the leading bioactive flavonoids with a therapeutic potential
implicated to an array of bioactivities investigated by a series of preclinical and clinical …

Chalcones: Promising therapeutic agents targeting key players and signaling pathways regulating the hallmarks of cancer

AA WalyEldeen, S Sabet, HM El-Shorbagy… - Chemico-Biological …, 2023 - Elsevier
The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

A review on mechanisms of anti tumor activity of chalcones

R Sharma, R Kumar, R Kodwani… - Anti-Cancer Agents …, 2016 - ingentaconnect.com
Chalcones comprise a characteristic framework of 1, 3-diaryl-2-propen-1-one. They have
been heralded as promising anti cancer drugs and have received much attention in the field …

Heterocyclic chalcone analogues as potential anticancer agents

V Sharma, V Kumar, P Kumar - Anti-Cancer Agents in Medicinal …, 2013 - ingentaconnect.com
Chalcones, aromatic ketones and enones acting as the precursor for flavonoids such as
Quercetin, are known for their anticancer effects. Although, parent chalcones consist of two …

An update on antitumor activity of naturally occurring chalcones

EH Zhang, RF Wang, SZ Guo… - … Based Complementary and …, 2013 - Wiley Online Library
Chalcones, which have characteristic 1, 3‐diaryl‐2‐propen‐1‐one skeleton, are mainly
produced in roots, rhizomes, heartwood, leaves, and seeds of genera Angelica, Sophora …