Purification of a meningeal cell‐derived chondroitin sulphate proteoglycan with neurotrophic activity for brain neurons and its identification as biglycan

U Junghans, A Koops, A Westmeyer… - European Journal of …, 1995 - Wiley Online Library
Serum‐free cultures of meningeal fibroblasts synthesize and release a chondroitin sulphate
proteoglycan (CSPG) that markedly enhances survival but not adhesion of embryonic rat …

Cultured astrocytes express biglycan, a chondroitin/dermatan sulfate proteoglycan supporting the survival of neocortical neurons

A Koops, J Kappler, U Junghans, G Kuhn… - Molecular brain …, 1996 - Elsevier
Astrocyte-conditioned medium (ACM) supports the survival of rat E15 neocortical neurons.
Using a microtiter assay for neuronal survival, we demonstrated that part of the survival …

Core protein of chondroitin sulfate proteoglycan promotes neurite outgrowth from cultured neocortical neurons

N Iijima, A Oohira, T Mori, K Kitabatake… - Journal of …, 1991 - Wiley Online Library
Chondroitin sulfate proteoglycan (CS‐PG) was purified from rat brain and examined for its
effect on neurite outgrowth in primary cultures of embryonic rat neocortical neurons. Neurite …

Large chondroitin sulfate proteoglycans of developing chick CNS are expressed in cerebral hemisphere neuronal cultures

AK Hennig, D Mangoura, NB Schwartz - Developmental brain research, 1993 - Elsevier
Chondroitin sulfate proteoglycans (CSPG) of the extracellular matrix may play regulatory
roles in central nervous system (CNS) development. We have examined the expression of …

Inhibition and enhancement of neural regeneration by chondroitin sulfate proteoglycans

H Rauvala, M Paveliev, J Kuja-Panula… - Neural regeneration …, 2017 - journals.lww.com
The current dogma in neural regeneration research implies that chondroitin sulfate
proteoglycans (CSPGs) inhibit plasticity and regeneration in the adult central nervous …

Inhibitory effects of brain chondroitin sulfate proteoglycans on neurite outgrowth from PC12D cells

A Oohira, F Matsui, R Katoh-Semba - Journal of Neuroscience, 1991 - Soc Neuroscience
Soluble chondroitin sulfate proteoglycans (CSPGs), prepared from 10-d-old rat brain, were
added to the culture medium of PC12D cells containing NGF to examine the effects on NGF …

Chondroitin sulphate proteoglycans in the rat brain: candidates for axon barriers of sensory neurons and the possible modification by laminin of their actions

R Katoh‐Semba, M Matsuda, K Kato… - European Journal of …, 1995 - Wiley Online Library
The addition of chondroitin sulphate proteoglycans (CSPGs), purified from the rat brain, to
the culture medium of PC12D cells inhibited their proliferation and neurite outgrowth …

Growth factor and cytokine regulation of chondroitin sulfate proteoglycans by astrocytes

GM Smith, C Strunz - Glia, 2005 - Wiley Online Library
After injury to the adult central nervous system (CNS), numerous cytokines and growth
factors are released that contribute to reactive gliosis and extracellular matrix production. In …

Developmentally regulated expression of a brain specific species of chondroitin sulfate proteoglycan, neurocan, identified with a monoclonal antibody 1G2 in the rat …

A Oohira, F Matsui, E Watanabe, Y Kushima, N Maeda - Neuroscience, 1994 - Elsevier
The mammalian brain contains many species of proteoglycan. To identify each proteoglycan
species, we have raised monoclonal antibodies against soluble chondroitin sulfate …

Chondroitin sulphate proteoglycans in the central nervous system: changes and synthesis after injury

F Properzi, RA Asher, JW Fawcett - Biochemical Society …, 2003 - portlandpress.com
Chondroitin sulphate proteoglycans (CSPGs) are up-regulated in the central nervous system
after injury, specifically around the lesion site where the glial scar forms. This structure …