Use of topical insulin to normalize corneal epithelial healing in diabetes mellitus
IS Zagon, MS Klocek, JW Sassani… - Archives of …, 2007 - jamanetwork.com
Objective To determine whether topical application of insulin normalizes delayed corneal
wound healing in rats with diabetes mellitus (DB). Methods Diabetes mellitus was induced …
wound healing in rats with diabetes mellitus (DB). Methods Diabetes mellitus was induced …
Insulin treatment ameliorates impaired corneal reepithelialization in diabetic rats
IS Zagon, JW Sassani, PJ McLaughlin - Diabetes, 2006 - Am Diabetes Assoc
Patients with diabetes are at an increased risk for developing corneal disorders, often as a
result of surgical and nonsurgical trauma. This study investigated whether intensive …
result of surgical and nonsurgical trauma. This study investigated whether intensive …
[HTML][HTML] Usage of topical insulin for the treatment of diabetic keratopathy, including corneal epithelial defects
CY Leong, AA Naffi, WHWA Halim… - World Journal of …, 2023 - ncbi.nlm.nih.gov
BACKGROUND Diabetic keratopathy (DK) occurs in 46%-64% of patients with diabetes and
requires serious attention. In patients with diabetes, the healing of corneal epithelial defects …
requires serious attention. In patients with diabetes, the healing of corneal epithelial defects …
Randomized controlled trial of topical insulin for healing corneal epithelial defects induced during vitreoretinal surgery in diabetics
S Fai, A Ahem, M Mustapha, UKM Noh… - The Asia-Pacific …, 2017 - journals.lww.com
Purpose: To determine the effect of topical insulin of 3 concentrations [0.5, 1, and 2 units per
drop 4 times per day (QID)] on postoperative corneal epithelial wound healing in diabetic …
drop 4 times per day (QID)] on postoperative corneal epithelial wound healing in diabetic …
Naltrexone and insulin are independently effective but not additive in accelerating corneal epithelial healing in type I diabetic rats
MS Klocek, JW Sassani, PJ McLaughlin… - Experimental eye …, 2009 - Elsevier
Patients with diabetes are at increased risk for developing corneal disorders, termed
diabetic keratopathy. Treatments for diabetic keratopathy are limited. Preclinical studies …
diabetic keratopathy. Treatments for diabetic keratopathy are limited. Preclinical studies …
Impaired epithelial wound healing and EGFR signaling pathways in the corneas of diabetic rats
K Xu, XY Fu-Shin - Investigative ophthalmology & visual …, 2011 - iovs.arvojournals.org
Purpose.: The purpose of the study was to investigate the effects of hyperglycemia on EGFR
(epidermal growth factor receptor)-mediated wound response and signal transduction in the …
(epidermal growth factor receptor)-mediated wound response and signal transduction in the …
Fibronectin facilitates corneal epithelial wound healing in diabetic rats
M NAKAMURA, N SATO, TAII CHIKAMA… - Experimental eye …, 1997 - Elsevier
To determine whether the effect of fibronectin on corneal epithelial healing occurs in eyes
affected by diabetes, the effect of fibronectin on the rates at which corneal epithelial wounds …
affected by diabetes, the effect of fibronectin on the rates at which corneal epithelial wounds …
Insulin facilitates corneal wound healing in the diabetic environment through the RTK-PI3K/Akt/mTOR axis in vitro
C Peterson, HL Chandler - Molecular and cellular endocrinology, 2022 - Elsevier
Diabetic patients can develop degenerative corneal changes, termed diabetic keratopathy,
during the course of their disease. Topical insulin has been shown to reduce corneal wound …
during the course of their disease. Topical insulin has been shown to reduce corneal wound …
Topical insulin, a novel corneal epithelial regeneration agent in dry eye disease
B Burgos-Blasco, D Diaz-Valle… - European Journal …, 2024 - journals.sagepub.com
Objective To evaluate the efficacy of insulin eye drops for dry eye disease in reducing
corneal staining and improving symptoms. Methods In this retrospective case series …
corneal staining and improving symptoms. Methods In this retrospective case series …
[HTML][HTML] Insulin, not leptin, promotes in vitro cell migration to heal monolayer wounds in human corneal epithelium
LJ Shanley, CD McCaig, JV Forrester… - … ophthalmology & visual …, 2004 - arvojournals.org
purpose. To investigate the effects of insulin and leptin on in vitro wound healing of
transformed human corneal epithelial cell monolayers and to identify cellular (migration …
transformed human corneal epithelial cell monolayers and to identify cellular (migration …
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