Contributions by the brain renin-angiotensin system to memory, cognition, and Alzheimer's disease

JW Wright, JW Harding - Journal of Alzheimer's Disease, 2019 - content.iospress.com
Alzheimer's disease (AD) is a neurodegenerative disease characterized by progressive
neuron losses in memory-associated brain structures that rob patients of their dignity and …

Brain angiotensin II and angiotensin IV receptors as potential Alzheimer's disease therapeutic targets

J Royea, E Hamel - Geroscience, 2020 - Springer
Alzheimer's disease (AD) is a neurodegenerative disorder that is multifactorial in nature. Yet,
despite being the most common form of dementia in the elderly, AD's primary cause remains …

Renin-angiotensin system and Alzheimer's disease pathophysiology: from the potential interactions to therapeutic perspectives

VT Ribeiro, LC de Souza… - Protein and Peptide …, 2020 - ingentaconnect.com
New roles of the Renin-Angiotensin System (RAS), apart from fluid homeostasis and Blood
Pressure (BP) regulation, are being progressively unveiled, since the discoveries of RAS …

Angiotensins in Alzheimer's disease–friend or foe?

PG Kehoe, S Miners, S Love - Trends in neurosciences, 2009 - cell.com
The renin–angiotensin system (RAS) is an important regulator of blood pressure.
Observational and experimental studies suggest that alterations in blood pressure and …

The renin-angiotensin system and antihypertensive drugs in Alzheimer's disease: current standing of the angiotensin hypothesis?

PG Kehoe, PA Passmore - Journal of Alzheimer's Disease, 2012 - content.iospress.com
There is an urgent need to improve upon Alzheimer's disease (AD) treatments. Limitations of
existing drugs are that they target specific downstream neurochemical abnormalities while …

Roles of brain angiotensin II in cognitive function and dementia

M Mogi, J Iwanami, M Horiuchi - International Journal of …, 2012 - Wiley Online Library
The brain renin‐angiotensin system (RAS) has been highlighted as having a pathological
role in stroke, dementia, and neurodegenerative disease. Particularly, in dementia …

[HTML][HTML] Therapeutic Implications of Renin–Angiotensin System Modulators in Alzheimer's Dementia

DC Ababei, V Bild, I Macadan, A Vasincu, RN Rusu… - Pharmaceutics, 2023 - mdpi.com
The Renin–Angiotensin System (RAS) has attracted considerable interest beyond its
traditional cardiovascular role due to emerging data indicating its potential involvement in …

[HTML][HTML] Brain renin–angiotensin system at the intersect of physical and cognitive frailty

C Cosarderelioglu, LS Nidadavolu… - Frontiers in …, 2020 - frontiersin.org
The renin–angiotensin system (RAS) was initially considered to be part of the endocrine
system regulating water and electrolyte balance, systemic vascular resistance, blood …

[HTML][HTML] Targeting brain Renin-Angiotensin System for the prevention and treatment of Alzheimer's disease: Past, present and future

F Gouveia, A Camins, M Ettcheto, J Bicker… - Ageing Research …, 2022 - Elsevier
Alzheimer's disease (AD) is a well-known neurodegenerative disease characterized by the
presence of two main hallmarks–Tau hyperphosphorylation and Aβ deposits …

Angiotensin as a target for the treatment of Alzheimer's disease, anxiety and depression

PR Gard - Expert opinion on therapeutic targets, 2004 - Taylor & Francis
The brain renin–angiotensin system (RAS), which is comprised of a variety of peptides
including angiotensin II, angiotensin III and angiotensin IV acting on AT1, AT2 and AT4 …