Relevance of mitogen-activated protein kinases ERK, JNK, and p38 in the regulation of
myeloid differentiation. The MAPKs are a family of serine/threonine kinases that play an …

Mitogen-activated protein (Map) kinases are widely expressed serine-threonine kinases that
mediate important regulatory signals in the cell. Three major groups of Map kinases exist …

Activation of the MEK/ERK/MAP kinase signaling pathway promotes the proliferation and
survival of hematopoietic cells. The kinases MEK-1, MEK-2, ERK-1/MAPK and ERK-2/MAPK …

The c-Jun amino-terminal kinases (JNKs)/stress-activated protein kinases (SAPKs) play a
crucial role in stress responses in mammalian cells. The mechanism underlying this …

Mitogen-activated protein kinases (MAPKs) regulate diverse cellular programs including
embryogenesis, proliferation, differentiation and apoptosis based on cues derived from the …

Mitogen-activated protein kinases (MAPKs) are components of sequential kinase cascades
that are activated in response to a variety of extracellular signals. Members of the MAPK …

The ERK, p38MAPK, JNK mitogen-activated protein kinases (MAPKs) are intracellular
signaling pathways that play a pivotal role in many essential cellular processes such as …

Abstract p38 MAP kinase (p38) and JNK have been described as playing a critical role in the
response to a variety of environmental stresses and proinflammatory cytokines. It was …

Activation of the mitogen-activated protein (MAP) kinase pathway has been associated with
both cell proliferation and differentiation. Constitutively activated forms of Mek (MAP …

Cancer is characterized as a complex disease caused by coordinated alterations of multiple
signaling pathways. The Ras/RAF/MEK/ERK (MAPK) signaling is one of the best-defined …