Human chromosome 11q23 translocations disrupting MLL result in poor prognostic
leukemias. It fuses the common MLL N-terminal∼ 1400 amino acids in-frame with> 60 …

Background Mixed lineage leukemia (MLL) gene translocations are found in~ 75% infant
and 10% adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 …

MLL (ALL-1) chimeric fusions and MLL partial tandem duplications (PTD) may have
mechanistically distinct contributions to leukemogenesis. Acute myeloid leukemia (AML) …

Acute lymphoblastic leukemia (ALL) with 11q23 translocations is usually associated with
MLL gene rearrangement, but little is known about its leukemogenesis. We analyzed the …

The MLL gene, located at 11q23 band, is frequently disrupted by different chromosomal
rearrangements that occur in a variety of hematological malignancies. MLL rearrangements …

PURPOSE: To determine the molecular characteristics, clinical features, and treatment
outcomes of children with acute lymphoblastic leukemia (ALL) and the t (11; 19)(q23; p13. 3) …

Chromosomal rearrangements of the human KMT2A/MLL gene are associated with de novo
as well as therapy-induced infant, pediatric, and adult acute leukemias. Here, we present the …

Important biological and pathologic properties are often conserved across species. Although
several mouse leukemia models have been well established, the genes deregulated in both …

Abstract Introduction: MLL-rearranged (MLL-r) acute leukemia in children is characterized by
young age at presentation and a poor overall prognosis despite multi-agent chemotherapy …

The hematological malignancies classified as mixed lineage leukemias (MLL) harbor
fusions of the MLL1 gene to partners that are members of transcriptional elongation …