Protein signaling networks are formed from diverse and inter-connected cell signaling
pathways converging into webs of function and regulation. These signaling pathways both …

Part of the cellular response to toxins, physical stresses and inflammatory cytokines occurs
by signalling via the stress-activated protein kinase (SAPK) and p38 reactivating kinase …

The p38 MAPK protein kinases affect a variety of intracellular responses, with well-
recognized roles in inflammation, cell-cycle regulation, cell death, development …

The p38 MAPK kinase pathway is activated in response to a wide range of cellular stress
stimuli and cytokines. Our understanding of the important functions of p38 MAPK in the …

The antiapoptotic role of Bcl-2 can be regulated by its phosphorylation in serine and
threonine residues located in a nonstructured loop that links BH3 and BH4 domains. p38 …

A stress-activated serine/threonine protein kinase, p38 mitogen-activated protein kinase
(p38 MAPK), belongs to the MAP kinase superfamily. Diverse extracellular stimuli, including …

The p38 family is a highly evolutionarily conserved group of mitogen-activated protein
kinases (MAPKs) that is involved in and helps co-ordinate cellular responses to nearly all …

The SAPKs represent novel conduits through which the effects of cellular insults or injury are
transmitted to the nucleus to influence gene expression. The SAPK pathway consists of at …

The p38 MAPK (mitogen-activated protein kinase) signalling pathway allows cells to
interpret a wide range of external signals and respond appropriately by generating a …

Abstract p38 MAPKs are a conserved subfamily of MAPKs involved in the response to stress
found in eukaryotic cells from yeast to mammals. The recent isolation of genes coding for …