Cholesterol metabolism in T cells
A Bietz, H Zhu, M Xue, C Xu - Frontiers in immunology, 2017 - frontiersin.org
Compartmentalization and spatial control of biochemical reactions is the foundation of cell-
based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps …
based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps …
Transcriptional regulation of T-cell lipid metabolism: implications for plasma membrane lipid rafts and T-cell function
GA Robinson, KE Waddington, I Pineda-Torra… - Frontiers in …, 2017 - frontiersin.org
It is well established that cholesterol and glycosphingolipids are enriched in the plasma
membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation …
membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation …
Cholesterol membrane content has a ubiquitous evolutionary function in immune cell activation: the role of HDL
Cholesterol membrane content has a ubiquitous evolutionary f... : Current Opinion in Lipidology
Cholesterol membrane content has a ubiquitous evolutionary function in immune cell activation …
Cholesterol membrane content has a ubiquitous evolutionary function in immune cell activation …
Impact of cholesterol metabolism in immune cell function and atherosclerosis
M Aguilar-Ballester, A Herrero-Cervera, Á Vinué… - Nutrients, 2020 - mdpi.com
Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …
[HTML][HTML] Cholesterol metabolism in innate and adaptive response
A Reboldi, E Dang - F1000Research, 2018 - ncbi.nlm.nih.gov
It has been long recognized that cholesterol is a critical molecule in mammalian cell biology,
primarily for its contribution to the plasma membrane's composition and its role in assuring …
primarily for its contribution to the plasma membrane's composition and its role in assuring …
The role of lipid metabolism in shaping the expansion and the function of regulatory T cells
A Pinzon Grimaldos, S Bini, I Pacella… - Clinical and …, 2022 - academic.oup.com
Metabolic inflammation, defined as a chronic low-grade inflammation, is implicated in
numerous metabolic diseases. In recent years, the role of regulatory T cells (Tregs) as key …
numerous metabolic diseases. In recent years, the role of regulatory T cells (Tregs) as key …
Regulation of T cell signalling by membrane lipids
The plasma membrane is an essential cellular structure that separates the cell interior from
the extracellular environment, while allowing for the exchange of signals and materials that …
the extracellular environment, while allowing for the exchange of signals and materials that …
Cholesterol depletion disrupts lipid rafts and modulates the activity of multiple signaling pathways in T lymphocytes
PS Kabouridis, J Janzen, AL Magee… - European journal of …, 2000 - Wiley Online Library
Lipid rafts are specialized plasma membrane microdomains, in which glycosphingolipids
and cholesterol are major structural components. In T lymphocytes, several signaling …
and cholesterol are major structural components. In T lymphocytes, several signaling …
Cellular cholesterol enrichment impairs T cell activation and chemotaxis
DH Nguyen, JC Espinoza, DD Taub - Mechanisms of ageing and …, 2004 - Elsevier
Human aging is associated with an increase in immune cell cholesterol levels, independent
of circulating cholesterol levels. The effects of such an increase in membrane cholesterol on …
of circulating cholesterol levels. The effects of such an increase in membrane cholesterol on …
Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response
J Surls, C Nazarov-Stoica, M Kehl, C Olsen, S Casares… - PloS one, 2012 - journals.plos.org
Cell signaling for T-cell growth, differentiation, and apoptosis is initiated in the cholesterol-
rich microdomains of the plasma membrane known as lipid rafts. Herein, we investigated …
rich microdomains of the plasma membrane known as lipid rafts. Herein, we investigated …