Compartmentalization and spatial control of biochemical reactions is the foundation of cell-
based life on earth. The lipid bilayer system employed by eukaryote cells not only keeps …

It is well established that cholesterol and glycosphingolipids are enriched in the plasma
membrane (PM) and form signaling platforms called lipid rafts, essential for T-cell activation …

Cholesterol membrane content has a ubiquitous evolutionary f... : Current Opinion in Lipidology
Cholesterol membrane content has a ubiquitous evolutionary function in immune cell activation …

Cholesterol, the most important sterol in mammals, helps maintain plasma membrane fluidity
and is a precursor of bile acids, oxysterols, and steroid hormones. Cholesterol in the body is …

It has been long recognized that cholesterol is a critical molecule in mammalian cell biology,
primarily for its contribution to the plasma membrane's composition and its role in assuring …

Metabolic inflammation, defined as a chronic low-grade inflammation, is implicated in
numerous metabolic diseases. In recent years, the role of regulatory T cells (Tregs) as key …

The plasma membrane is an essential cellular structure that separates the cell interior from
the extracellular environment, while allowing for the exchange of signals and materials that …

Lipid rafts are specialized plasma membrane microdomains, in which glycosphingolipids
and cholesterol are major structural components. In T lymphocytes, several signaling …

Human aging is associated with an increase in immune cell cholesterol levels, independent
of circulating cholesterol levels. The effects of such an increase in membrane cholesterol on …

Cell signaling for T-cell growth, differentiation, and apoptosis is initiated in the cholesterol-
rich microdomains of the plasma membrane known as lipid rafts. Herein, we investigated …