Receptor activator of NF-κB (RANK) ligand (RANKL) induces the differentiation of monocyte/
macrophage–lineage cells into the bone–resorbing cells called osteoclasts. Because …

Since the receptor activator of nuclear factor-kappa B ligand (RANKL), its cognate receptor
activator of nuclear factor-kappa B (RANK), and the decoy receptor osteoprotegerin (OPG) …

Bone‐related diseases, such as osteoporosis and rheumatoid arthritis, affect hundreds of
millions of people worldwide and pose a tremendous burden to health care. By deepening …

Understanding of osteoclast formation and activation has advanced considerably since the
discovery of the RANKL/RANK/OPG system in the mid 1990s. Osteoblasts and stromal stem …

Almost a quarter century has passed since discovery of receptor activator of NF-κB ligand
(RANKL). This discovery had a major impact on identification of mechanisms regulating …

Discovery and characterization of the cytokine receptor-cytokine-decoy receptor triad formed
by receptor activator of nuclear factor kappa-B ligand (RANKL)–receptor activator of NF-κB …

The receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK-osteoprotegerin
(OPG) system is critical to bone homeostasis, but genetically deficient mouse models have …

The past decade has seen an explosion in the field of bone biology. The area of bone
biology over this period of time has been marked by a number of key discoveries that have …

Although it has long been recognized that inflammation, a consequence of immune‐driven
processes, significantly impacts bone turnover, the degree of centralization of skeletal and …

It is important to understand the molecular mechanisms regulating osteoclast formation, as
excess activation of osteoclasts is associated with various osteopenic disorders. Receptor …