Proneurotrophins bind with high affinity to p75 neurotrophin receptor (p75NTR) and lack the
capacity to bind Trk receptors, suggesting that proneurotrophins can elicit apoptosis via …

Proneurotrophins and mature neurotrophins activate different signaling pathways with
distinct effects on their target cells: proneurotrophins can induce apoptotic signaling via …

Neurons respond to numerous factors in their environment that influence their survival and
function during development and in the mature brain. Among these factors, the …

Seizure-induced damage elicits a loss of hippocampal neurons mediated to a great extent
by the p75 neurotrophin receptor (NTR). Proneurotrophins, which are potent apoptosis …

Nerve growth factor (NGF) and related neurotrophins influence neuronal survival and
differentiation via interactions with the trk family of receptors. Recent studies have …

Neurotrophins promote survival and suppress apoptosis in many populations of neurons.
Currently, phosphatidylinositol-3 kinase (PI-3K) is recognized as the main mediator of this …

Recent evidence indicates that naturally occurring neuronal death in mammals is regulated
by the interplay between receptor-mediated prosurvival and proapoptotic signals. The …

At vanishingly low concentrations, factors of the neurotrophin family (NGF, BDNF, NT3 and
NT4/5) can promote neuronal survival or death. Many investigations indicate that the …

Although mature neurotrophins are well described trophic factors that elicit retrograde
survival signaling, the precursor forms of neurotrophins (ie, proneurotrophins) can function …

Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …