Cryptococcosis, caused by Cryptococcus neoformans, has been demonstrated to be
controlled by T helper (Th) 1 cells while Th2 cells are associated with fungal growth and …

Cryptococcus neoformans is an opportunistic fungal pathogen that causes life-threatening
pneumonia and meningoencephalitis in immune compromised individuals. Previous studies …

Cryptococcal infections are primarily caused by two related fungal species: Cryptococcus
neoformans and Cryptococcus gattii. It is well known that C. neoformans generally affects …

Host defense mechanisms to the important fungal pathogen Cryptococcus neoformans are
complex and incompletely understood. From in vitro studies, we could expect CD8+ T cells …

Cryptococcus neoformans, the etiological agent of cryptococcosis, is an occasional
opportunistic fungal pathogen of immune competent individuals. However, it is a relatively …

Cryptococcosis is a fungal disease caused by multiple Cryptococcus serotypes; particularly
C. neoformans (serotypes A and D) and C. gattii (serotypes B and C). To date, there is no …

Tumor necrosis factor alpha (TNF-α) plays a critical role in the control of cryptococcal
infection, and its insufficiency promotes cryptococcal persistence. To explore the therapeutic …

The fungal genus Cryptococcus comprises a group of pathogens with considerable
phenotypic and genotypic diversity that can lead to cryptococcosis in both healthy and …

We evaluated cell-mediated immune (CMI) responses in mice given a pulmonary infection
with a Cryptococcus neoformans strain engineered to produce the Th1-type cytokine gamma …

Understanding more about the host's immune response to different Cryptococcus spp. will
provide additional insight into the pathogenesis of cryptocococcis. We hypothesized that the …